103. Guide to Occupations
Chapter Editors: Alexander Donagi, Avraham Aladjem and Menachem Schwartz
Table of Contents
Systematization of Occupational Hazards by Occupation
Alexander Donagi and Avraham Aladjem
Ambulance Driver (Medical services)
Animal Handler
Automobile Mechanic
Boiler Operator
Chauffeur
Electrical-Appliance Repairer
Gardener
Glazier
Gluer
Heavy-Truck and Lorry Driver
Laboratory Worker
Model Maker
Painter (Non-Art)
Pest Exterminator
Plumber
Sanitarian
Solderer and Brazer
Welder
104. Guide to Chemicals
Chapter Editors: Jean Mager Stellman, DebraOsinsky and Pia Markkanen
Jean Mager Stellman, DebraOsinsky and Pia Markkanen
Guide to Units and Abbreviations
Table of Contents
Sulphur is found in the native state in certain volcanic regions, or in the combined state as metal sulphides (pyrites, galena, blende, cinnabar), sulphates (anglesite, gypsum) or in the form of hydrogen sulphide in certain sources of water or natural gas. At one time, the mined sulphur-bearing rock was heated to melting point in primitive furnaces dug in the ground or in masonry furnaces open at the top (Sicilian calcaroni), the sulphur-bearing rock being covered with a layer of lag to prevent contact with the air. In both cases, some of the natural sulphur is itself consumed as fuel.
Elemental sulphur is largely extracted from petroleum refining. In some countries, sulphur is recovered as a by-product in the production of copper, lead and zinc, from their sulphur minerals; it is also obtained by roasting iron pyrites for the production of sulphuric acid.
Uses
Sulphur is used for the production of sulphuric acid, sulphates, hyposulphites, carbon disulphide and so on, in match manufacture, rubber vulcanization, electron melting and incendiary-bomb manufacture; it is used in agriculture to combat plant parasites and in the treatment of wine. It is also used as a bleaching agent for pulp and paper, textiles and dried fruit. Sulphur is a component of anti-dandruff shampoos, a binder and asphalt extender for road paving, an electric insulator, and a nucleating agent in photographic film.
Sulphur dioxide serves primarily as an intermediate in the production of sulphuric acid, but is also encountered in the production of paper pulp, starch, sulphites and thiosulphates. It is used as a bleaching agent for sugar, fibres, leather, glues and sugar liquor; in organic synthesis it is used as the starting point for numerous substances such as carbon disulphide, thiophene, sulphones and sulphonates; it is employed as a preservative in the wine and food industries. In combination with ammonia and atmospheric moisture, it forms artificial ammonium sulphite mists used to protect crops against night frost. Sulphur dioxide is used as a disinfectant in breweries, a depressant in the flotation of sulphide ores, an extractive solvent in oil refining, a cleaning agent for tile drains, and a tanning agent in the leather industry.
Sulphur trioxide is used as an intermediate in the manufacture of sulphuric acid and oleum for sulphonation, in particular, of dyes and dye-stuffs, and for the production of anhydrous nitric acid and explosives. Solid sulphur trioxide is marketed under such names as Sulphan and Triosul, and is used primarily for sulphonation of organic acids. Sulphur tetrafluoride is a fluorinating agent. Sulphur hexafluoride serves as a gaseous insulator in high-voltage electric installations. Sulphyryl fluoride is used as an insecticide and a fumigant.
Sulphur hexafluoride and trioxychlorofluoride are used in insulation material for high-voltage systems.
Many of these compounds are used in the dye-stuff, chemical, leather, photography, rubber and metalworking industries. Sodium metabisulphite, sodium trisulphite, sodium hydrosulphite, ammonium sulphate, sodium thiosulphate, calcium sulphate, sulphur dioxide, sodium sulphite and potassium metabisulphite are additives, preservatives and bleaching agents in the food industry. In the textile industry, sodium trisulphite and sodium sulphite are bleaching agents; ammonium sulphate and ammonium sulphamate are used for flameproofing; and sodium sulphite is used for printing cotton. Ammonium sulphate and carbon disulphide are used in the viscose silk industry, and sodium thiosulphate and sodium hydrosulphite are bleaching agents for pulp and paper. In addition, ammonium sulphate and sodium thiosulphate are tanning agents in the leather industry, and ammonium sulphamate is used for flameproofing wood and treating cigarette paper.
Carbon disulphide is a solvent for waxes, lacquers, oils and resins, as well as a flame lubricant for cutting glass. It is used for the cold vulcanization of rubber and for generating petroleum catalysts. Hydrogen sulphide is an additive in extreme-pressure lubricants and cutting oils, and a by-product of petroleum refining. It is used in ore reduction and for the purification of hydrochloric acid and sulphuric acid.
Hazards
Hydrogen sulphide
Hydrogen sulphide is a flammable gas which burns with a blue flame, giving rise to sulphur dioxide, a highly irritating gas with a characteristic odour. Mixtures of hydrogen sulphide and air in the explosive range may explode violently; since the vapours are heavier than air, they may accumulate in depressions or spread over the ground to a source of ignition and flash back. When exposed to heat, it decomposes to hydrogen and sulphur, and when in contact with oxidizing agents such as nitric acid, chlorine trifluoride and so on, it may react violently and ignite spontaneously. Extinguishing agents recommended for the fighting of hydrogen sulphide fires include carbon dioxide, chemical dry powder and water sprays.
Health hazards. Even at low concentrations, hydrogen sulphide has an irritant action on the eyes and respiratory tract. Intoxication may be hyperacute, acute, subacute or chronic. Low concentrations are readily detected by the characteristic rotten-egg odour; however, prolonged exposure dulls the sense of smell and makes the odour a very unreliable means of warning. High concentrations can rapidly deaden the sense of smell. Hydrogen sulphide enters the body through the respiratory system and is rapidly oxidized to form compounds of low toxicity; there are no accumulation phenomena, and elimination occurs through the intestine, urine and the expired air.
In cases of slight poisoning, following exposure to from 10 to 500 ppm, a headache may last several hours, pains in the legs may be felt and rarely there may be loss of consciousness. In moderate poisoning (from 500 to 700 ppm) there will be loss of consciousness lasting a few minutes, but no respiratory difficulty. In cases of severe poisoning the subject drops into a profound coma with dyspnoea, polypnoea and a slate-blue cyanosis until breathing restarts; there are tachycardia and tonic-clonic spasms.
Inhalation of massive quantities of hydrogen sulphide will rapidly produce anoxia resulting in death by asphyxia; epileptiform convulsions may occur and the individual falls apparently unconscious, and may die without moving again. This is a syndrome characteristic of hydrogen sulphide poisoning in sewer workers; however, in such cases, exposure is often due to a mixture of gases including methane, nitrogen, carbon dioxide and ammonia.
In subacute poisoning, the signs may be nausea, stomach distress, foetid eructations, characteristic “rotten-egg” breath, and diarrhoea. These digestive-system disorders may be accompanied by balance disorders, vertigo, dryness and irritation of the nose and throat with viscous and mucopurulent expectoration and diffuse rales and ronchi.
There have been reports of retrosternal pain similar to that found in angina pectoris, and the electrocardiogram may show the characteristic trace of myocardial infarction, which, however, disappears quite rapidly. The eyes are affected by palpebral oedema, bulbar conjunctivitis and mucopurulent secretion with, perhaps, a reduction in visual acuity—all of these lesions usually being bilateral. This syndrome is known to sugar and sewer workers as “gas eye”. A variety of other systemic effects have been reported, including headaches, asthenia, eye disorders, chronic bronchitis and a grey-green line on the gums; as in acute poisoning, the ocular lesions are said to predominate, with paralysis, meningitis, polyneuritis and even behavioural problems.
In rats, exposure to hydrogen sulphide has given rise to teratogenic effects.
Metabolism and pathology. Hydrogen sulphide has a general toxic action. It inhibits Warburg’s respiratory enzyme (cytochrome oxidase) by binding iron, and the oxydo-reduction processes are also blocked. This inhibition of enzymes essential for cellular respiration may be fatal. The substance has a local irritant action on the mucous membranes since, on contact with moisture, it forms caustic sulphides; this may also occur in the lung parenchyma as a result of combination with tissue alkalis. Experimental research has shown that these sulphides may enter into the circulation, producing respiratory effects such as polypnoea, bradycardia and hypertension, by their action on the vasosensitive, reflexogenic zones of the carotid nerves and Hering’s nerve.
Post-mortem examination in a number of cases of hyperacute poisoning has revealed pulmonary oedema and congestion of various organs. A characteristic autopsy feature is the odour of hydrogen sulphide that emanates from the dissected corpse. Other features of note are the haemorrhages of the gastric mucosae, and the greenish colour of the upper regions of the intestine and even of the brain.
Carbon disulphide
The first cases of carbon disulphide poisoning were observed during the nineteenth century in France and Germany in connection with the vulcanization of rubber. After the First World War, the production of viscose rayon expanded, and with it the incidence of acute and chronic poisoning from carbon disulphide, which has remained a serious problem in some countries. Acute and, more often, chronic poisoning still occur, although improvements in technology and hygienic conditions in plants have virtually eliminated such problems in a number of countries.
Carbon disulphide is primarily a neurotoxic poison; therefore those symptoms indicating central and peripheral nervous system damage are the most important. It was reported that concentrations of 0.5 to 0.7 mg/l (160 to 230 ppm) caused no acute symptoms in humans, 1 to 1.2 mg/l (320 to 390 ppm) were bearable for several hours, with the appearance of headaches and unpleasant feelings after 8 hours of exposure; at 3.6 mg/l (1,150 ppm) giddiness set in; at 6.4 to 10 mg/l (2,000 to 3,000 ppm) light intoxication, paraesthesia and irregular breathing occurred within 1/2 to 1 hour. At concentrations of 15 mg/l (4,800 ppm), the dose was lethal after 30 minutes; and at even higher concentrations, unconsciousness occurred after several inhalations.
Acute poisoning occurs mainly after accidental exposures to very high concentrations. Unconsciousness, frequently rather deep, with extinction of cornea and tendon reflexes, occurs after only a short time. Death sets in by a blockage of the respiratory centre. If the patient regains consciousness, motor agitation and disorientation follow. If he or she recovers, frequently late sequellae include psychic disturbances as well as permanent damage to the central and peripheral nervous systems. Subacute cases of poisoning usually occur from exposure to concentrations of more than 2 mg/l. They are manifested mainly in mental disorders of the manic-depressive type; more frequent at lower concentrations, however, are cases of polyneuritis.
Chronic poisoning begins with weakness, fatigue, headache, sleep disturbances, often with frightening dreams, paraesthesia and weakness in the lower extremities, loss of appetite and stomach illness. Neurological symptoms are also seen, and impotence is rather frequent. Continued exposure may give rise to polyneuritis, which is said to appear after working in concentrations of 0.3 to 0.5 mg/l for several years; an early sign is the dissociation of tendon reflexes in lower extremities. Damage to the brain nerves is less frequent, but neuritis n. optici and vestibular and sense-of-smell disturbances have been observed.
In exposed workers, disorders occur in the male reproductive system (hypo- and asthenospermia), and excretion of 17-ketosteroids, 17-hydroxycorticosteroids and androsteron decreases during exposure. In women menstrual disturbances, metrorrhagia and more frequent abortions have been described. Carbon disulphide passes the placenta. Animals have demonstated foetotoxic and teratogenic effects at levels of 32 ppm and higher.
The relationship between carbon disulphide and atherosclerosis is a topic of special interest. Prior to the Second World War, not much attention was paid to this pattern, but thereafter, when classic carbon disulphide poisoning ceased to occur in many countries, several authors noted the development of atherosclerosis of the brain vessels in younger workers in viscose rayon plants.
Ophthalmodynamographic studies in young workers who were exposed to carbon disulphide concentrations of 0.2 to 0.5 mg/l for several years, showed that the retinal systolic and diastolic blood pressure was higher than that of the brachial artery. This increase was due to arterial hypertension in the brain, and it was reported that arterial spasms appeared before subjective complaints. Rheoencephalography has been recommended for assessment of brain vessel function. Changes in resistance are caused by arterial pulsation, especially of intracranial vessels, and could therefore lead to the discovery of possible increased rigidity or spasms of cranial vessels. In Japanese workers a higher incidence of small, round, retinal haemorrhages and microaneurysms was observed.
In chronically exposed men, arteriolocapillary hyalinosis was found, which represents a special type of carbon disulphide arteriosclerosis. Therefore, carbon disulphide may be assumed to be a contributing factor to the origin of this sclerosis, but not a direct cause. This hypothesis, as well as the results of biochemical examinations, seems to be supported further by reports about the significant increase of atherosclerosis, frequently in younger persons who were exposed to carbon disulphide. With regard to the kidneys, it seems that glomerulosclerosis of the Kimmelstiel-Wilson type is more frequent in persons exposed to carbon disulphide than in others. British, Finnish and other investigators have shown that there is increased mortality from coronary heart disease in male workers exposed for many years to relatively low carbon disulphide concentrations.
The absorption of carbon disulphide through the respiratory tract is rather high, and about 30% of the inhaled quantity is retained when a steady state of inhalation is reached. The time required for the establishment of this state varies in length from rather short, to several hours if light physical work is done. After termination of exposure, part of the carbon disulphide is rapidly excreted through the respiratory tract. The length of the desaturation period depends on the degree of exposure. Approximately 80 to 90% of the absorbed carbon disulphide is metabolized in the body with the formation of dithiocarbamates and possible further cyclization to thiazolidane. Owing to the nucleophilic character of carbon disulphide, which reacts especially with —SH, —CH, and —NH2 groups, perhaps other metabolites are formed too.
Carbon disulphide is also absorbed through the skin in considerable amounts, but less than through the respiratory tract. Dithiocarbamates easily chelate many metals such as copper, zinc, manganese, cobalt and iron. Increased zinc content has been demonstrated in the urine of animals and humans exposed to carbon disulphide. It is also believed that a direct reaction takes place with some of the metals contained in metalloenzymes.
Liver microsome tests have demonstrated the formation of carbon oxysulphide (COS) and atomic sulphur which is bound covalently to microsomal membranes. Other authors have found in rats that carbon disulphide after oxidative decomposition binds primarily to protein P-450. In urine it is excreted in a fraction of 1% as carbon disulphide; of the retained amount it is excreted to about 30% as inorganic sulphates, the remainder as organic sulphates and some unknown metabolites, one of which is thiourea.
It is assumed that the reaction of carbon disulphide with vitamin B6 is very important. B6 metabolism is impaired, which is manifested by enhanced excretion of xanthurenic acid and decreased excretion of 4-pyridoxine acid, and further in a reduced serum pyridoxine level. It appears that copper utilization is disturbed as indicated by the reduced level of ceruloplasmin in exposed animals and humans. Carbon disulphide interferes with serotonin metabolism in the brain by inhibiting certain enzymes. Furthermore, it has been reported that it inhibits the clearing factor (lipase activated by heparin in the presence of -lipoproteins), thus interfering with the clearing of fat from blood plasma. This may result in the accumulation of cholesterol and lipoid substances in vessel walls and stimulate the atherosclerotic process. However, not all reports about the inhibition of the clearing factor are so convincing. There are many, although often contradictory, reports about the behaviour of lipoproteins and cholesterol in the blood and organs of animals and humans exposed to carbon disulphide for a long time, or poisoned by it.
Impaired glucose tolerance of the chemical diabetes type has also been observed. It is elicited by the elevated level of xanthurenic acid in serum, which, as was demonstrated in experiments, forms a complex with insulin and reduces its biological activity. Neurochemical studies have demonstrated changed catecholamine levels in the brain as well as in other nervous tissues. These findings show that carbon disulphide changes the biosynthesis of catecholamines, probably by inhibiting dopamine hydroxylase by chelating enzymatic copper.
Examination of animals poisoned by carbon disulphide revealed a variety of neurologic changes. In humans the changes included serious degeneration of the grey matter in the brain and cerebellum, changes in the pyramid system of pons and spinal cord, degenerative changes of peripheral nerves and disintegration of their sheaths. Also described were atrophy, hypertrophy and hyalin degeneration of muscle fibres.
Sulphur and sulphur dioxide
Extraction of sulphur-bearing rock can lead to the inhalation of the high concentrations of sulphur dust in sulphur mines and may have harmful effects on the respiratory system. In sulphur mining, at the beginning of exposure, the miner suffers from upper respiratory tract catarrh, with cough, and expectoration which is mucoid and may even contain grains of sulphur. Asthma is a frequent complication.
The acute effects of inhalation of sulphur and its inorganic compounds include upper respiratory system effects (catarrhal inflammation of the nasal mucosae, which may lead to hyperplasia with abundant nasal secretion). Tracheobronchitis is a frequent occurrence, with shortness of breath (dyspnoea), persistent cough and expectoration which may sometimes be streaked with blood. There may also be irritation of the eyes, with lacrimation, photophobia, conjunctivitis and blepharoconjunctivitis; cases of damage to the crystalline lens have also been described, with the formation of opacities and even cataract and focal chorioretinitis.
The skin may be subject to erythematous and eczematous lesions and signs of ulceration, especially in the case of workers whose hands are in prolonged or repeated contact with powdered sulphur or sulphur compounds, as for example in bleaching and decolouring processes in the textile industry.
Sulphur dioxide is one of the most widely encountered contaminants in the workplace environment. It is released in considerable quantities in the manufacture of sulphuric acid, liquid sulphur dioxide and cast iron, in the refining of sulphur-rich minerals (copper, lead, zinc and so on) and from the combustion of sulphur-rich coal. It is also found as a contaminant in the production of cellulose, sugar and superphosphates, in food preserving, petroleum refining, bleaching, disinfecting and so on.
Sulphur dioxide is an irritant gas, and its effect is due to the formation of sulphurous and sulphuric acids on contact with moist mucosae. It may enter the body via the respiratory tract or, following dilution in the saliva, it may be swallowed and enter the gastro-intestinal tract in the form of sulphurous acid. Certain authors believe that it can enter the body via the skin. Due to its high solubility, sulphur dioxide is rapidly distributed throughout the body, producing metabolic acidosis with a reduction in the blood alkali reserve and compensatory elimination of ammonia in the urine and alkali in the saliva. The general toxic action is demonstrated by protein and carbohydrate metabolism disorders, vitamin B and C deficiency and oxidase inhibition. In the blood, sulphuric acid is metabolized to sulphates which are excreted in the urine. It is probable that the absorption of large quantities of sulphur dioxide has a pathological effect on the haemopoietic system and may produce methaemoglobin.
Acute poisoning results from the inhalation of very high concentrations of sulphur dioxide and is characterized by intense irritation of the conjunctivae and upper respiratory tract mucosae with dyspnoea and cyanosis followed rapidly by consciousness disorders. Death may ensue as a result of suffocation due to reflex spasm of the larynx, sudden circulatory arrest in the lungs, or shock.
In industry, sulphur dioxide poisoning is usually of a chronic nature. The substance’s local irritant action on the mucous membranes produces a sensation of burning, dryness and pain in the nose and throat, altered sense of smell, and causes secretion (which may be blood-streaked), nasal haemorrhage, and dry or productive cough, perhaps with bloody sputum. Gastric troubles have also been reported. Objective signs and symptoms include pronounced hyperaemia accompanied by oedema of the mucous membranes of the nose, pharyngeal walls, tonsils and, in some cases, also the larynx. Chronic conjunctivitis can be observed. In the more advanced stages, the process becomes atrophic, with dilation of the blood vessels in certain regions. Ulceration of the nasal septum, which bleeds readily, may also be observed. Persons who have a long history of exposure to high concentrations of sulphur dioxide may suffer from chronic bronchitis accompanied by emphysema. The initial symptoms are a reduction in vital capacity to the detriment of residual volume, compensatory hyperventilation and a reduction in oxygen consumption.
These manifestations often precede the radiological stage, which presents with dense and enlarged hilar shadows, gross reticulation produced by peribronchitis and, in some cases, bronchiectasis and even nodular appearances. These changes are bilateral and more evident in the median and basal regions.
Both behavioural and nervous system disorders may occur, probably due to the general toxic effect of sulphur dioxide on the body.
The mouth can be affected, with dental caries, peridontal and gingival disorders present. Patients may complain of rapid and painless dental destruction, loss of fillings, and increased tooth sensitivity to temperature changes. Objective symptoms include loss of brilliance, and enamel striation and yellowing.
Sulphur dioxide causes skin irritation which is aggravated by perspiration, and this may be attributed to the conversion of sulphur dioxide to sulphurous acid from contact with sweat.
The initial upper and lower respiratory tract symptoms may regress with suitable treatment and removal from exposure to all sources of respiratory tract inflammation; however, the prognosis is poor for the advanced forms—especially when accompanied by bronchiectasis and right heart deficiency.
The chronic effects consist mainly of bronchopulmonary disease which, after several years, may be complicated by emphysema and bronchiectasis. The maxillary and frontal sinuses may be affected; involvement is usually bilateral, and pansinusitis may be observed in some cases. X-ray examination of the respiratory system reveals irregular opacities, especially in the medial basal region; the apical regions are not usually affected. In certain cases, nodulation has been observed. Stratigraphy shows that the accentuation of pulmonary pattern depends on pulmonary vascular repletion.
Lung function examination has shown changes in pulmonary ventilation, increased oxygen consumption, reduced expiratory volume per second and increased residual volume. Pulmonary carbon dioxide diffusion capacity was also impaired. The disorders are often of a spasmodic nature. Levels of blood sulphur may be higher than normal; there is increased urinary excretion of sulphates and a rise in the ratio of total to organic sulphur.
Sulphur dust and sulphur dioxide are definitely at the origin of the chronic bronchitis. They irritate the mucous membranes and produce obstructive reactions. The possibility of sulphur-induced pulmonary sclerosis has been much discussed, and sulphur pneumoconiosis (“thiopneumoconiosis”) was described for the first time a century ago. However, experimental research and autopsy findings have shown that sulphur produces chronic bronchopulmonary disease without the formation of true nodular fibrosis and without any feature characteristic of silicosis.
Other sulphur compounds
Sulphur trioxide. The vapour pressure of sulphur trioxide rises rapidly with increasing temperatures and, when the a-form melts, the pressure rise is explosive; consequently transport and storage containers must withstand pressures of 10 to 15 atm. Sulphur trioxide reacts vigorously and highly exothermically with water to produce hydrosulphuric acid. When exposed to moist air, it fumes and forms a mist of sulphuric acid which eventually fills all the available space; it also corrodes metals. It is a powerful oxidizing agent and, in the liquid phase, carbonizes organic materials.
Wherever it is used in gaseous, liquid or solid form, or when oleum or hot sulphuric acid is being employed, sulphur trioxide will pollute the working environment. Sulphur dioxide in air will be oxidized by atmospheric oxygen to produce sulphur trioxide.
It enters the body through the respiratory tract and acts both as a local irritant and general toxic agent in a similar manner to sulphur dioxide, although its irritant action is more pronounced. It causes chronic respiratory tract damage and may degrade alkaline reserves and carbohydrate and protein metabolism; it is metabolized to sulphate in the blood and eliminated in the urine in the same way as sulphur dioxide.
The toxic action of oleum on the body is similar to that of sulphuric acid, but the objective signs and symptoms are more pronounced. Safety and health measures for sulphur trioxide are similar to those described for sulphur dioxide.
Carbonyl sulphide (COS). Carbonyl sulphide is encountered in the native state in volcanic gases and sulphurous waters. It is produced by the reaction of dilute sulphuric acid on ammonium thiocyanate. Carbonyl sulphide is known for its high toxicity. It has been found that it produces serious nervous-system impairment with narcotic effects in high concentrations and has an irritant action.
It is a potent oxidizing substance and should be handled appropriately.
Sulphur tetrafluoride, sulphur pentafluoride (S2F10), disulphur decafluoride, sulphuryl fluoride
(SO2F2), sulphuric oxyfluoride and thionyl fluoride (SOF2) are all irritant substances capable of causing pulmonary oedema in concentrations exceeding the exposure limits, because of their absence of water solubility. The most dangerous is sulphur pentafluoride, which in the presence of moisture hydrolyzes into hydrogen fluoride and sulphur dioxide; its irritant action is considered more severe than that of phosgene, not only as regards the dose, but also because pulmonary haemorrhages may be associated with lung oedema. Sulphuryl fluoride appears to act mainly as a convulsant agent on laboratory animals.
The safety and health measures to be taken in exposure to sulphur pentafluoride are the same as those recommended for the most severe irritant compounds. The other fluorinated sulphur compounds should be treated like sulphur dioxide.
Sulphur chloride is a flammable liquid which gives rise to a moderate fire hazard associated with the evolution of the dangerous decomposition products sulphur dioxide and hydrogen chloride. It is a fuming, corrosive liquid which is dangerous to the eyes; the vapour is irritating to the lungs and mucous membrane. In contact with the skin, the liquid can cause chemical burns. It should be handled under the maximum degree of enclosure and workers should be provided with personal protective equipment including eye protective equipment and respiratory protective equipment.
Sulphuryl chloride is formed by the direct combination of sulphur dioxide and chlorine in the presence of a catalyst which may be charcoal, camphor or acetic anydride. It is also obtained by heating chlorosulphonic acid, with mercuric sulphate, antimony or tin as catalyst. It is used in the manufacture of pharmaceuticals and dye-stuffs, and generally in organic synthesis as a chlorinating, dehydrating or acylating agent.
Sulphuryl chloride is a corrosive liquid which, in contact with the body, can cause burns; the vapour is a respiratory irritant. The precautions are similar to those recommended for sulphur chloride.
Safey and Health Management
Airborne sulphur dust is a fire and explosion hazard; there is also the danger of insidious release of sulphur dioxide leading to the inhalation of irritant vapours. Vapours given off during the melting of sulphur may contain sufficient hydrogen sulphide and carbon disulphide to permit ignition of the air/vapour mixture on contact with a hot surface; such an ignition may result in the transmission of flames to the molten sulphur.
The main hazards in the handling, transport and storage of molten sulphur are related to the flammability of the substance and the possible giving off, during cooling, of hydrogen sulphide, which is even more readily flammable and is explosible in air at concentrations ranging between 4.3 and 45%. Workers employed in sulphur extraction should have at their disposal suitable self-contained respiratory protective apparatus—in particular for rescue operations. Smoking should be prohibited during the transport and handling of sulphur and in sulphur storage areas. Contact of liquid or flowered sulphur with a source of ignition should be avoided, and sulphur stores should not be located in the vicinity of oxidizing agents. The loading and unloading of liquid sulphur necessitate special fire prevention and protection measures. Transport and storage of sulphur require proper grounding (earthing) procedures, exhaust of hydrogen sulphide and regular monitoring of its concentration, and protection of tanks against corrosion by hydrogen sulphide.
Sulphur is a poor conductor of electricity and tends to develop charges of static electricity during transport or processing; static discharges may lead to the ignition of sulphur dust. Pyrophoric deposits of ferrous sulphur which form on the tank wall are also a hazard. Fires in heaps of sulphur are frequent and insidious since they may break out again even after the original conflagration has ostensibly been extinguished.
Carbon disulphide is also highly flammable and explosive.
Sulphur dioxide management efforts should be directed primarily at reducing gas emission and ensuring sufficient ventilation to maintain sulphur dioxide concentrations at the workplace below maximum permissible levels. Total enclosure of processes is an effective and desirable technique. Respiratory protective equipment should be provided where workers may, under exceptional circumstances, be exposed to dangerous concentrations.
Precautions should be taken to prevent the emission of sulphur dust into the atmosphere, and the use of respirators is recommended if the atmospheric dust concentration exceeds the exposure level.
Pre-employment examination should ensure that persons suffering from bronchitis or asthma are not exposed to sulphur. In the periodic examination, clinical examination should be supplemented by chest x ray. These contraindications should also be borne in mind during the periodic medical examinations, which should be carried out at appropriate intervals.
Inorganic sulphur compounds tables
Table 1 - Chemical information.
Table 2 - Health hazards.
Table 3 - Physical and chemical hazards.
Table 4 - Physical and chemical properties.
Thiols (mercaptans, thioalcohols or sulphydrates) are monofunctional organic sulphydryl compounds, either aliphatic or aromatic, and characterized by the presence of sulphydryl (–SH) groups. Generally, the thiols have a strong, unpleasant odour even at very low concentrations. At equal concentrations the strength of the odour appears to vary inversely with the number of carbon atoms in the molecule, and is essentially absent in 1-dodecane thiol and higher thiols. The most important method for the production of thiols involves the reaction of hydrogen sulphide with olefins or alcohols, at various temperatures and pressures, in combination with a variety of catalysts and promoters including acids, bases, peroxides and metal sulphates. The hydrogen of the –SH group can be replaced by mercury (the word mercaptans is derived from the Latin corpus mercurium captans, meaning entity-seizing mercury) and other heavy metals to form mercaptides.
Naturally occurring thiols exist in all living systems. In living cells, most of the thiols are contributed by the amino acid cysteine and the tripeptide glutathione. Also, methanethiol and ethanethiol occur naturally as “sour” gas at room temperature, while the other thiols are liquids. The C1 through C6 alkane thiols and benzenethiol have obnoxious odours at much lower concentrations than do the other thiols.
Organic sulphur compounds can also be formed when a sulphate unit (SO4) is bound to an organic group. Sulphides and sulphonium salts are formed with two organic groups bonded to a sulphur atom.
Uses
Organic sulphides and sulphates are used in industry as solvents, chemical intermediates, flavouring agents and accelerants for rubber vulcanization and in plating baths for coating metals.
The mercaptans are primarily used as chemical intermediates in the manufacture of jet fuels, insecticides, fungicides, fumigants, dyes, pharmaceuticals and other chemicals, and as adroitness for odourless, toxic gases. Amyl mercaptan (1-pentanethiol), ethyl mercaptan and tert-butyl mercaptan (2-methyl-2-propanethiol) are used as adroitness for natural gas, while propel mercaptan (propanethiol) and methyl mercaptan function as odourants and warning agents for other odourless, toxic gases. Methyl mercaptan is also used as a synthetic flavouring agent and as an intermediate in the manufacture of pesticides, jet fuels, fungicides and plastics. Phenyl mercaptan is an intermediate for insecticides, fungicides and pharmaceuticals. 1-Dodecanethiol (dodecyl mercaptan) is utilized in the manufacture of synthetic rubber, plastics, pharmaceuticals, insecticides, fungicides and nonionic detergents. It also serves as a complexing agent for the removal of metals from wastes.
Thioglycolic acid is used in the production of permanent creases in textiles and in biological media for growing micro-organisms. It finds use in permanent hair wave solutions, plastics, pharmaceuticals, and as a reagent for the detection of iron and other metal ions.
Dimethyl sulphate (sulphuric acid dimethyl ether), an oily, colourless liquid that is slightly soluble in water but more soluble in organic solvents, is used primarily for its methylating properties. It is used in the manufacture of methyl esters, ethers and amines; in dyes, drugs and perfumes; phenol derivatives; and other chemicals. It is also used as a solvent in the separation of mineral oils.
Tetramethylthiuram disulphide (TTD, TMTD, Thiram, thirad, thiuram, Disulphuram), a white or yellow crystal insoluble in water but soluble in organic solvents, is used as a rubber accelerator and vulcanizer, a disinfectant for fruit, seeds, nuts and mushrooms, a bacteriostat for edible oils and fats, and as an ingredient in sun-tan and antiseptic sprays, soaps and lotions. It is also used as a fungicide, a rodent repellent and wood preservative.
Ethylene thiourea (2-imadazolidin ethione) and thiourea serve as components of electroplating baths. Ethylene thiourea also finds use in the dye-stuff and pharmaceutical industries, while thiourea has numerous applications in the photography, textile, cosmetics and paper industries. Thiourea is used to remove stains from negatives and as a fixing agent in photography, hair preparations, dry-cleaning chemicals, paper whiteners and in treatments for boiler water and wastewater, to prepare non-glare mirrors, to prevent brown stain in hemlock wood, as a weighting agent for silk and as a fire retardant for textiles.
Dimethyl sulphide (methyl sulphide) is used as a gas odourant and a food additive. Allyl propyl disulphide is another food additive, and dimethyl sulphoxide (methyl sulphoxide) (DMSO) is a solvent found in industrial cleaners, pesticides, paint and varnish removers, and antifreeze or hydraulic fluid when mixed with water. 2,4-Diaminoanisole sulphate (m-phenylediamine-4-methoxy-sulphate) is used in dyeing furs, and sodium lauryl sulphate (sulphuric acid monododecyl ester sodium salt) is an emulsifying agent used in metal processing, detergents, shampoos, creams, pharmaceuticals and foods.
Hazards
Thiols (mercaptans)
Industrial processes involving the use of thiols present several types of potential problems, including fire and explosion, as well as adverse effects on the health of workers.
Fire and explosion. Most of the thiols are flammable substances. With the alkane thiols, the vapour pressure decreases as the molecular weight increases. At normal work room temperatures the lower molecular weight thiols (C2 through C6) may vaporize to form explosive mixtures with air. The mercaptans are typically flammable liquids except for methyl mercaptan, which is a gas. A strong unpleasant odour is their prime characteristic.
Health hazards. Thiols have an intensely disagreeable odour, and contact with the liquid or vapour may cause irritation of the skin, eyes and mucous membranes of the upper respiratory tract. Liquid thiols can also cause contact dermatitis. Benzenethiol appears to have stronger irritating properties than the alkane thiols.
All thiols behave as weak acids, and the predominant biological effect is on the central nervous system. Inhalation is of special concern with the C1 through C6 group of alkane thiols, while skin exposure is of greatest concern with the higher thiols (C7 through C12, C16, C18). Benzenethiol is the most toxic of the thiols normally found in the workplace and has a marked potential for causing eye injury.
Accidental exposure of workers to high concentrations of thiols (greater than 50 ppm) have caused muscular weakness, nausea, dizziness and narcosis. Systemically, methanethiol acts like hydrogen sulphide and may depress the central nervous system, resulting in respiratory paralysis and death. Because hydrogen sulphide is a raw material used or generated in thiol manufacturing plants, special precautions are necessary to prevent its release in hazardous concentrations. After an acute exposure, if death is not immediate, irritation of the lower respiratory tract may result in pulmonary oedema which may be delayed and, if not treated promptly, fatal. Victims who survive may have liver and kidney damage and may suffer from headache, dizziness, staggering gait, nausea and vomiting.
Thioglycolic acid. Pure thioglycolic acid has a pronounced irritant effect on the skin and mucous membranes; in dilute form its irritant action is less pronounced. The salts (ammonium, sodium) of the acid have been reported to cause skin lesions including discreet pruriginous, papulopustular and vesicular eruptions of the neck, ears and shoulders of persons having undergone permanent waving. More rarely, isolated lesions of the deep-burn type and contact eczema of the hands, lower arms, face and neck have been seen in hairdressers.
The thioglycolates widely found in trade have a very low sensitizing action and cause dermatitis by primary irritation. It has been reported, however, that the hydrazide and glycolics esters of thioglycolic acid have a pronounced sensitizing action and have resulted in numerous cases of contact eczema amongst hairdressers. As a consequence, the sale of preparations containing the hydrazide was stopped in Germany. Thioglycolic acid derivatives have also, on rare occasions, caused perionyxis and dry skin of the hands in hairdressers. When dermatitis is encountered in a hairdresser, however, thought should also be given to the other products used in permanent waving, excessive alkalinity, and sodium hydrosulphide impurities.
Thioglycolic acid has a high degree of acute toxicity. The oral LD50 of the undiluted acid in rats has been reported as less than 50 mg/kg. It is rapidly absorbed through the skin and, in the rabbit, 60% is excreted in the urine within 24 hours in the form of inorganic sulphate or neutral sulphur.
Prevention. Hairdressers should use thioglycolic acid or its derivatives only in dilute solutions with a pH near to neutral. In Switzerland, for example, they are permitted to use only 7.5% solutions with a maximum pH of 7.5 or 9% solutions with a maximum pH of 8. When applying the solution, the hairdresser should protect his or her hands by the use of rubber or plastic gloves, and eye contact should be avoided. The solution should be neutralized as quickly as possible, and flushed away at the first indication of irritation.
Hairdressers using these products should be informed of the hazards involved and should be alert for early signs of trouble (i.e., burning sensations, itching and so on). These preparations should not be used if there is any pre-existing skin irritation. In hairdressing salons, ventilation should be sufficient to prevent the material from accumulating in the atmosphere in the form of mist.
Sulphates and sulphides
Dimethyl sulphate is an extremely hazardous poison. Its toxicity is derived from its alkylating properties and its hydrolysis to sulphuric acid and methyl alcohol. The liquid is highly irritating to skin and mucous membranes. In the skin it causes blisters which are typically slow-healing and may result in scars, and numbness which may persist for months. Irritation of the eye may result in tearing (lacrimation), light sensitivity (photophobia), conjunctivitis and keratitis; in severe cases, corneal opacities and permanent impairment of vision have occurred. In addition to acute irritation of the respiratory tract, it may cause delayed pulmonary oedema, bronchitis and pneumonitis. The effect of the vapour on trigeminal, laryngeal and vagal nerve endings may result in bradycardia or tachycardia and pulmonary vasodilatation.
Long-term effects are seen only rarely and are usually limited to respiratory and ocular difficulties.
Dimethyl sulphate has been shown to be carcinogenic in the rat both directly and following prenatal exposure. The inhalation of 1 ppm was followed by urinary excretion of methylpurines showing a non-specific alkylation of DNA. The International Agency for Research on Cancer (IARC) classifies dimethyl sulphate as a Group 2A chemical, probably carcinogenic to humans.
Tetramethylthiuram disulphide (TTD). Exposure to TTD is by inhalation of its dust, spray or mist. Local effects result from irritation of mucous membranes: conjunctivitis, rhinitis, sneezing, cough. TTD ranges high among substances giving rise to contact hypersensitivity, perhaps reflecting the frequent use of rubber in domestic, medical and industrial utensils. It may produce contact dermatitis, erythema and urticaria; skin sensitivity is confirmed by patch testing.
Workers exposed to TTD have shown an intolerance to alcohol, manifested by flushing of the face, palpitation, rapid pulse, hypotension and dizziness. These effects are thought to be due to the blocking of the oxidation of acetaldehyde. (The diethyl homologue of TTD is marketed under the name of Antabuse as a drug to be administered to chronic alcoholics in the hope that the severely disagreeable symptoms that follow their ingestion of alcohol will condition them against breaking their abstinence.)
Intoxication due to inhalation or ingestion of TTD results in nausea, vomiting, diarrhoea, ataxia, hypothermia, hypotonia and, finally, ascending paralysis with death from respiratory failure. Toxicity is greater in the presence of fats, oils and fat solvents. TTD is metabolically converted to carbon disulphide, to which the neurologic and cardiovascular effects are attributed.
Safety and Health Measures
Open flames and other ignition sources should be excluded from areas where flammable sulphur compounds (e.g., thiols), especially the more volatile ones, are used. Emergency procedures and routine work practices should emphasize proper handling, containment of spills, and the use of proper protective equipment, such as respirators and eye goggles. Spills of thiols should be neutralized with a household bleach solution and flushed with an abundant flow of water. The primary purpose of control measures is to reduce the potential for inhalation or skin contact with thiols, with special emphasis on the eyes. Whenever feasible, control at the source of exposure should be implemented; this may involve enclosure of the operation and/or the use of local exhaust ventilation. Where such engineering controls are not sufficient to reduce airborne concentrations to acceptable levels, respirators may be necessary to prevent pulmonary irritation and systemic effects. At low concentrations (less than 5 ppm) a chemical cartridge respirator with a half-mask facepiece and organic vapour cartridges can be used. At high concentrations, supplied air respirators, with a full facepiece, are necessary.
Safety showers, eyewash fountains and fire extinguishers should be located in areas where appreciable amounts of thiols are used. Handwashing facilities, soap and ample amounts of water should be made available to involved employees.
Treatment. Affected employees should, as necessary, be removed from emergency situations and if the eyes or skin have been contaminated they should be lavaged with water. Contaminated clothing should be promptly removed. If high concentrations are inhaled, hospitalization and observation should be continued for at least 72 hours because of the potential delayed onset of severe pulmonary oedema. Therapeutic measures should follow those suggested for respiratory irritants.
Protective measures are similar to those for sulphur dioxide. They include the wearing of impervious clothing, aprons, gloves, goggles and boots by those working where liquid thiols are likely to be spilled or splashed.
All industrial operations involving the use of dimethyl sulphate should be carried out in fully enclosed systems, and established procedures for the handling of human carcinogens should be followed. Arrangements should be made for proper disposal of any spillage, and workers should be strictly forbidden to attempt to clean up massive spillages such as may occur in the event of container breakage until the area has been thoroughly washed down. Many accidents with dimethyl sulphate have been the result of hasty and uninformed clean-up attempts.
Organic sulphur compounds tables
Table 1 - Chemical information.
Table 2 - Health hazards.
Table 3 - Physical and chemical hazards.
Table 4 - Physical and chemical properties.
After oxygen, silicon is the element most frequently found on earth. It does not occur free in nature, but as an oxide (silica) or silicate (feldspar, kaolinite and so on) in sand, rock and clay. One method of preparation is by heating quartz (SiO2) with carbon; during this process carbon monoxide is emitted and raw silicon (98% pure) remains. This grade is sufficiently pure for incorporation in alloys—for example, of aluminium and iron—in order to make them harder or less brittle. Pure silicon is prepared by heating raw silicon in chlorine. During this process the volatile compound SiCl4 occurs and is separated by distillation. If this liquid is heated together with hydrogen, pure silicon is released. This is shaped into rod form, and the last impurities are “floated” out from the rod by successively heating small portions of it to melting point, in an atmosphere of inert gas, such as argon, compounded with any trace elements to be added, which become dissolved in the liquid silicon.
Siloxanes are compounds which contain oxygen in addition to hydrogen, silicon and, usually, carbon (although there are some inorganic siloxanes). Starting from small molecules, they can be built up into large units (polymers), to which various properties (liquidity, elasticity, stability and so on) can be imparted. Siloxanes exist in the form of resins, elastomers (rubbery compounds) or oils.
Uses
It is used as an alloying agent for steel, aluminium, copper, bronze and iron. It is also widely used in semiconductor manufacture and in the production of silanes and organosilicon compounds.
Organosilicon compounds are used in the form of resins, elastomers (rubbery compounds) or oils. Resins are organosilicon compounds which, when mixed with a number of other substances used in the paint industry (hardeners, accelerators and so on), form very stable layers and are readily applicable even on bases to which other paints generally do not adhere well (such as metal surfaces). In addition they are fairly resistant to momentary heating or attack by oxygen, and do not fade much in sunlight. Among other things, these resins are also used as moulding compounds (plastics), and in the manufacture of foams which display good resistance to high temperatures and are useful thermal insulators. Other resins are used as so-called foils (thin layers applied in the electronics industry) because of their low combustibility and good electrical insulating properties even in a damp environment. Silicon resins have numerous applications because of their heat stability and water repellency, and their resistance to solvents, high temperatures and sunlight. Silicon resins are used in paints, varnishes, moulding compounds (plastics), electrical insulation, pressure-sensitive and release coatings, and laminates.
Methyl silicate is a fairly volatile liquid used in the manufacture of television screens. When it is decomposed in water, a transparent layer of silicic acid results, which secures the screen to the glass wall. Ethyl silicate is used as a binding agent for making moulds in special metal-founding processes or as a starting point in chemical synthesis.
Hazards and Their Prevention
This section discusses the hazards of organosilicon compounds. The reader is referred elsewhere in the Encyclopaedia for discussions of the important health effects of exposure to silicates, particularly crystalline silicates. The effects of silicon carbides are also discussed elsewhere.
The toxicological hazards of metallic silicon are not known. For most regulatory purposes it is considered a nuisance dust. When silicon is prepared and purified in the absence of air, the process takes place in a sealed, gas-tight enclosure which should limit exposures. Hazards may arise from the chemicals which are used in conjunction with silicon in various manufacturing processes. There are three types of silicon compounds considered here: silanes, siloxanes and heterosiloxanes.
Silanes. Silanes contain hydrogen and silicon. Most of them are very stable, oily substances which in themselves find but little practical application. If chlorine, nitrogen and so on are added, however, they can be used for chemical synthesis. Both tetrachlorosilane and trichlorosilane, however, are highly reactive compounds that can emit a highly irritant asphyxiating vapour. When they come into contact with water they are decomposed (hydrolysis), giving off hydrogen chloride. Water in the atmosphere can initiate such hydrolysis. The hydrolysis products can be have intense effects on the eyes and respiratory tract. Moreover, trichlorosilane ignites readily. These liquids are treated as corrosive substances and are shipped in quartz ampoules or stainless steel boxes. Spills can be rendered harmless by anhydrous soda.
The siloxane oil vapours can be irritating to the eyes, and it is reported that extremely high concentrations can have serious effects on the respiratory system. By contrast the silicon resin compounds have been considered to be harmless in the past and were widely used as implants in the body.
Elastomers (rubbery compounds). These substances are characterized by their great stability at high (250 °C) and low temperatures (down to -75 °C), and resistance to attack by chemicals. Their chemical inertness is such that they are often used as implant material for blood vessels and so on. Moreover, they do not dissolve in many organic solvents, such as trichloroethylene or acetone. Silicone rubber membranes are easily permeable by gases such as oxygen, even when these are dissolved in water.
It should be noted that there have been major controversies and legal disputes over the effects of silicon breast implants, with noted authorities divided about any possible long-range health hazards.
Oils. These compounds also retain their stability when exposed to extreme changes in temperature. For this reason they are often used as lubricants, since their viscosity remains substantially constant at different temperatures. They are also used as water-repellents, applied for example on walls, textiles or leather. Pressed parts can be easily removed from moulds smeared with these compounds, and they also act as anti-foaming agents (the latter property is inter alia of assistance to chronic bronchitis sufferers, as inhalation of the vapours of these oils aids the evacuation of phlegm). In experimental animals it has been found that these substances are eliminated very slowly from the lungs, but that their presence there causes no adverse reactions. Ointments prepared with silicones are also very well tolerated and, by virtue of their water-repellent properties, contribute to prevention of—or recovery from—contact eczemas, since they prevent contact with substances causing reactions due to hypersensitivity.
Animal experiments also have indicated that if the vapour is inhaled in very high concentrations a fatal narcosis can result; if the exposed animals survived the narcosis, however, complete recovery ensued. Silicone oils irritate the ocular mucosae to a slight extent, giving rise to redness, painfulness and lacrimation; more serious symptoms are induced only by compounds of low molecular weight.
Heterosiloxanes. In addition to silicon, hydrogen and oxygen, heterosiloxanes contain certain other elements such as metals (aluminium, tin, lead and so on) as well as boron or arsenic, etc. They hydrolyze readily and are therefore dangerous to the human body, a major part of which consists of water. Heterosiloxanes are generally formed as intermediate products in chemical syntheses. Methyl silicate and ethyl silicate occupy a special place in this group. Methyl silicate, a fairly volatile liquid, is used in the manufacture of television screens. When it is decomposed in water, a transparent layer of silicic acid results, which secures the screen to the glass wall. Methyl silicate liquid or vapour which reaches the eyes produces no immediate effect, but after 10 to 12 h gives rise to violent ocular pain, accompanied by redness and tears. The cornea becomes opaque, and ulcers can occur, which may result in blindness. If the vapour is inhaled, fatal damage to the lungs or kidneys can ensue. Since contact with the vapour or liquid produces no immediate warning pain, special precautions are required with this substance. Breakage of flasks must be avoided. The eyes must be protected by gas-tight goggles, and the risk of inhalation of vapours in case of spillage, etc., must be avoided by installing an exhaust ventilation system.
Ethyl silicate, which is used as a binding agent for making moulds in special metal-founding processes or as a starting point in chemical syntheses, has a low vapour pressure; this physical property helps reduce exposure. In high concentrations it irritates the mucous membranes and the skin, and in very high concentrations it has proved fatal to animals.
As the molecular weight of the silicates increases, there is a decrease in reactivity.
Silicon and organosilicon compounds tables
Table 1 - Chemical information.
Table 2 - Health hazards.
Table 3 - Physical and chemical hazards.
Table 4 - Physical and chemical properties.
Chemical Formula |
Chemical |
Synonyms |
CAS-Number |
B(OH)3 |
BORIC ACID |
Boracic acid; |
10043-35-3 |
HClSO3 |
CHLOROSULPHURIC ACID |
Chlorosulphonic acid; |
7790-94-5 |
HFSO3 |
FLUOROSULPHURIC ACID |
Fluorosulphonic acid; |
7789-21-1 |
HCl |
HYDROCHLORIC ACID |
Anhydrous hydrochloric acid; |
7647-01-0 |
HBF4 |
HYDROFLUOBORIC ACID |
Borofluoric acid; |
16872-11-0 |
HNO3 |
NITRIC ACID |
Agua fortis; |
7697-37-2 |
HClO4 |
PERCHLORIC ACID |
Perchloric acid |
7601-90-3 |
H3PO4 |
PHOSPHORIC ACID |
Orthophosphoric acid |
7664-38-2 |
SiH2O3 |
SILICIC ACID |
Metasilicic acid; |
7699-41-4 |
NH2SO3 H |
SULFAMIC ACID |
Amidosulphonic acid; |
5329-14-6 |
H2SO4 |
SULPHURIC ACID |
Dihydrogen sulphate |
7664-93-9 |
Chemical Name Cas-Number |
ICSC Short Term Exposure |
ICSC Long Term Exposure |
ICSC Routes Of Exposure and Symptoms |
US NIOSH Target Organs & Routes Of Entry |
US NIOSH Symptoms |
HYDROCHLORIC ACID 7647-01-0 |
eyes; skin; resp tract; lungs |
lungs; teeth |
Inhalation: corrosive, burning sensation, cough, laboured breathing, shortness of breath, sore throat, symptoms may be delayed Skin: corrosive, serious skin burns, pain Eyes: corrosive, pain, blurred vision, severe deep burns |
resp sys; eyes; skininh, ing,(soln),con |
Irrit nose, throat, larynx; cough, choking; derm; soln: eye, skin burns; liq: frostbite; in animals: lar spasm; pulm edema |
NITRIC ACID 7697-37-2 |
Inhalation: corrosive, burning sensation, cough, laboured breathing, unconsciousness, symptoms may be delayed Skin: corrosive, serious skin burns, pain, yellow discolouration Eyes: corrosive, redness, pain, blurred vision, severe deep burns Ingestion: corrosive, abdominal pain, burning sensation, shock |
eyes; resp sys; skin; teethinh, ing, con |
Irrit eyes, skin, muc memb; delayed pulm edema, Pneuitis, bron; dental erosion |
||
PHOSPHORIC ACID 7664-38-2 |
eyes; skin; resp tract; lungs |
Inhalation: burning sensation, cough, laboured breathing, shortness of breath, sore throat, unconsciousness Skin: redness, pain, blisters Eyes: redness, pain, blurred vision, severe deep burns Ingestion: abdominal cramps, burning sensation, confusion, laboured breathing sore throat, unconsciousness, weakness |
resp sys; eyes; skininh, ing, con |
Irrit eyes, skin, upper resp sys; eye, skin burns; derm |
|
SULPHAMIC ACID 5329-14-6 |
eyes; skin; resp tract; lungs |
||||
SULPHURIC ACID 7664-93-9 |
eyes; skin; resp tract; lungs |
Inhalation: corrosive, burning sensation, cough, laboured breathing, sore throat Skin: corrosive, redness, serious skin burns, pain, severe deep burns Ingestion: corrosive, abdominal pain, burning sensation, vomiting, collapse |
resp sys; eyes; skin; teethinh, ing, con |
Irrit eyes, skin, nose, throat; pulm edema, bron; emphy; conj; stomatis; dental erosion; trachbronc; eye, skin burns; derm |
Chemical Name |
Physical |
Chemical |
UN Class Or Division / Subsidiary Risks |
CHLOROSULPHURIC ACID |
8 |
||
FLUOROSULPHURIC ACID |
8 |
||
HYDROCHLORIC ACID |
The gas is heavier than air |
The solution in water is a strong acid, it reacts violently with bases and is corrosive • Reacts violently with oxidants forming toxic gas (chlorine) • On contact with air it emits corrosive fumes (hydrochloric acid) • Attacks many metals forming combustible gas (HYDROGEN) |
8 |
HYDROFLUOBORIC ACID |
8 |
||
NITRIC ACID |
The substance decomposes on warming producing nitrogen oxides • The substance is a strong oxidant and reacts violently with combustible and reducing materials, eg, turpentine, charcoal, alcohol • The substance is a strong acid, it reacts violently with bases and is corrosive to metals • Reacts very violently with organic chemicals (eg, acetone, acetic acid, acetic anhydride), causing fire and explosion hazard • Attacks some plastics |
8 |
|
PERCHLORIC ACID |
5.1/ 8 |
||
PHOSPHORIC ACID |
The substance violently polymerizes under the influence of azo compounds, epoxides and other polymerizable compounds • On combustion, forms toxic fumes (phosphorous oxides) • The substance decomposes on contact with metals, alcohols, aldehydes, cyanides, ketones, phenols, esters, sulfides, halogenated organics producing toxic fumes • The substance is a medium strong acid • Attacks metals to liberate flammable hydrogen gas |
8 |
|
SULPHAMIC ACID |
8 |
||
SULPHURIC ACID |
On combustion, forms toxic fumes (sulphur oxides) • The substance is a strong oxidant and reacts violently with combustible and reducing materials • The substance is a strong acid, it reacts violently with bases and is corrosive to most common metals forming a flammable/explosive gas (hydrogen) • Reacts violently with water and organic materials with evolution of heat • Upon heating, irritating or toxic fumes (or gases) (sulphur oxides) are formed |
8 |
For UN Class: 1.5 = very insensitive substances which have a mass explosion hazard; 2.1 = flammable gas; 2.3 = toxic gas; 3 = flammable liquid; 4.1 = flammable solid; 4.2 = substance liable to spontaneous combustion; 4.3 = substance which in contact with water emits flammable gases; 5.1 = oxidizing substance; 6.1 = toxic; = radioactive; 8 = corrosive substance.
Chemical Name |
Colour/Form |
Boiling Point (ºC) |
Melting Point (ºC) |
Molecular Weight (g/mol) |
Solubility In Water |
Relative Density (water=1) |
Relative Vapour Density |
Vapour Pressure/ (Kpa) |
Inflam. Limits |
Flash Point (ºC) |
Auto Ignition Point (ºC) |
BORIC ACID |
colourless, transparent crystals or white granules or powder |
300 |
169 |
61.84 |
1 g/18 ml |
@ 15 ºC |
|||||
CARBONIC ACID |
63.03 |
sol |
|||||||||
CHLOROSULPHURIC ACID |
colourless or slightly yellow liquid |
@ 755 mm Hg |
-80 |
116.53 |
1.753 |
4.02 |
@ 32 ºC |
||||
FLUOROSULPHURIC ACID |
colourless liquid; reddish-brown colour with acetone |
163 |
-89 |
100.07 |
@ 25 ºC/4 ºC |
||||||
HYDROCHLORIC ACID |
colourless liquid |
-85 |
-114 |
36.46 |
82.3 g/100 ml |
@ 15 ºC/4 ºC |
1.3 |
||||
HYDROFLUOBORIC ACID |
colourless liquid |
130 |
87.82 |
misc |
1.84 |
||||||
NITRIC ACID |
transparent colourless or yellowish liquid |
83 |
-42 |
63.01 |
sol |
@ 25 ºC/4 ºC |
2-3 |
6.4 |
|||
PERCHLORIC ACID |
colourless, oily liquid |
@ 11 mm Hg |
-112 |
100.47 |
misc |
@ 22 ºC |
|||||
PHOSPHORIC ACID |
unstable orthorhombic crystals or clear syrupy liquid; at 20 deg C, the 50 and 75% strengths are mobile liquids, the 85% is of a syrupy consistency, while the 100% acid is in the form of crystals; viscous, colourless, odorless liquid |
213 |
42.4 |
98.00 |
v sol |
3.4 |
4.0 |
||||
SILICIC ACID |
jelly-like precipitate obtained when sodium silicate solution is acified during drying jelly is converted to a white amorphous powder. |
||||||||||
SULPHAMIC ACID |
orthorhombic crystals; white crystalline solid |
205 |
97.10 |
sol |
2.15 |
||||||
SULPHURIC ACID |
clear, colourless, oily liquid when pure but brownish in hue when impure |
290 |
10.4 |
98.08 |
sol |
1.841 |
3.4 |
0.13 |
Chemical Formula |
Chemical |
Synonyms |
CAS-Number |
64197 |
ACETIC ACID |
Ethanoic acid; |
64-19-7 |
108247 |
ACETIC ANHYDRIDE |
Acetanhydride; |
108-24-7 |
50782 |
ACETYLSALICYLIC ACID |
Acetosalic acid; |
50-78-2 |
79107 |
ACRYLIC ACID |
Ethylenecarboxylic acid; |
79-10-7 |
124049 |
ADIPIC ACID |
Adipinic acid; |
124-04-9 |
50817 |
L-ASCORBIC ACID |
3-Keto-l-gulofuranolactone; |
50-81-7 |
65850 |
BENZOIC ACID |
Benzenecarboxylic acid; |
65-85-0 |
107926 |
BUTYRIC ACID |
Butanic acid; |
107-92-6 |
142621 |
n-CAPROIC ACID |
Butylacetic acid; |
142-62-1 |
115286 |
CHLORENDIC ACID |
1,4,5,6,7,7-Hexachloro-5-norbornene-2,3-dicarboxylic acid; |
115-28-6 |
79118 |
CHLOROACETIC ACID |
Monochloroacetic acid; |
79-11-8 |
118912 |
o-CHLOROBENZOIC ACID |
2-CBA; |
118-91-2 |
535808 |
m-CHLOROBENZOIC ACID |
3-Chlorobenzoic acid |
535-80-8 |
74113 |
p-CHLOROBENZOIC ACID |
p-Carboxychlorobenzene; |
74-11-3 |
598787 |
2-CHLOROPROPIONIC ACID |
a-Chloropropionic acid |
598-78-7 |
94746 |
4-CHLORO-o-TOLOXYACETIC ACID |
4-Chloro-o-cresoxyacetic acid; |
94-74-6 |
77929 |
CITRIC ACID |
Citro; |
77-92-9 |
5949291 |
CITRIC ACID HYDRATE |
1,2,3-Propanetricarboxylic acid, 2-Hydroxy-, monohydrate |
5949-29-1 |
3724650 |
CROTONIC ACID |
a-Butenoic acid; |
3724-65-0 |
79436 |
DICHLORACETIC ACID |
Bichloracetic acid; |
79-43-6 |
94757 |
2,4-DICHLORPHENOXYACETIC ACID |
2,4-D; |
94-75-7 |
149575 |
2-ETHYLHEXOIC ACID |
Butylethylacetic acid; |
149-57-5 |
144490 |
FLUOROACETIC ACID |
Pymonic acid; |
144-49-0 |
64186 |
FORMIC ACID |
Aminic acid; |
64-18-6 |
110178 |
FUMARIC ACID |
trans-Butenedioic acid; |
110-17-8 |
149917 |
GALLIC ACID |
3,4,5-Trihydroxybenzoic acid |
149-91-7 |
79141 |
GLYCOLIC ACID |
Hydroxyacetic acid; |
79-14-1 |
111148 |
HEPTANOIC ACID |
n-Heptoic acid; |
111-14-8 |
79312 |
ISOBUTYRIC ACID |
Dimethylacetic acid; |
79-31-2 |
121915 |
ISOPHTHALIC ACID |
Benzene-1,3-dicarboxylic acid; |
121-91-5 |
143077 |
LAURIC ACID |
Dodecanoic acid; |
143-07-7 |
110167 |
MALEIC ACID |
cis-Butenedioic acid; |
110-16-7 |
108316 |
MALEIC ANHYDRIDE |
cis-Butenedioic anhydride; |
108-31-6 |
141822 |
MALONIC ACID |
Carboxyacetic acid; |
141-82-2 |
90642 |
MANDELIC ACID |
a-Hydroxyphenylacetic acid; |
90-64-2 |
79414 |
METHACRYLIC ACID |
Methacrylic acid; |
79-41-4 |
112050 |
NONANOIC ACID |
n-Nonylic acid; |
112-05-0 |
112801 |
9-OCTADECENOIC ACID |
cis-9-Octadecenoic acid; |
112-80-1 |
144627 |
OXALIC ACID |
Ethanedioic acid; |
144-62-7 |
57103 |
PALMITIC ACID |
Cetylic acid; |
57-10-3 |
88993 |
PHTHALIC ACID |
Benzene-1,2-dicarboxylic acid; |
88-99-3 |
85449 |
PHTHALIC ANHYDRIDE |
1,2-Benzenedicarboxylic acid anhydride; |
85-44-9 |
75989 |
PIVALIC ACID |
2,2-Dimethylpropanoic acid; |
75-98-9 |
79094 |
PROPIONIC ACID |
Carboxyethane; |
79-09-4 |
123626 |
PROPIONIC ANHYDRIDE |
Methylacetic anhydride; |
123-62-6 |
98737 |
p-tert-BUTYL BENZOIC ACID |
p-TBBA |
98-73-7 |
104154 |
p-TOLUENESULPHONIC ACID |
p-Methylbenzenesulfonic acid; |
104-15-4 |
69727 |
SALICYLIC ACID |
o-Hydroxybenzoic acid; |
69-72-7 |
57114 |
STEARIC ACID |
Cetylacetic acid; |
57-11-4 |
110156 |
SUCCINIC ACID |
butanedioic acid; |
110-15-6 |
121573 |
SULPHANILIC-ACID |
p-Aminobenzenesulphonic acid; |
121-57-3 |
87694 |
TARTARIC ACID |
2,3-Dihydrosuccinic acid; |
87-69-4 |
100210 |
TEREPHTHALIC ACID |
p-Benzenedicarboxylic acid; |
100-21-0 |
76039 |
TRICHLORACETIC ACID |
TCA |
76-03-9 |
93765 |
TRICHLOROPHENOXYACETIC ACID |
2,4,5-T |
93-76-5 |
76051 |
TRIFLUOROACETIC ACID |
Perfluoroacetic acid; |
76-05-1 |
552307 |
TRIMELLIC ACID ANHYDRIDE |
4-Carboxyphthalic anhydride; |
552-30-7 |
109524 |
VALERIC ACID |
Butanecarboxylic acid; |
109-52-4 |
Chemical Name CAS-Number |
ICSC Short-Term Exposure |
ICSC Long-Term Exposure |
ICSC Routes of Exposure and Symptoms |
US NIOSH Target Organs & Routes of Entry |
US NIOSH Symptoms |
ACETIC ACID 64-19-7 |
eyes; skin; resp tract; lungs |
skin |
Inhalation: sore throat, cough, shortness of breath, laboured breathing, symptoms may be delayed Skin: redness, serious skin burns, pain Eyes: pain, redness, blurred vision, severe deep burns Ingestion: abdominal pain, burning sensation, diarrhoea, sore throat, vomiting |
Resp sys; skin; eyes; teeth Inh; con |
Irrit eyes, nose, throat; eye, skin burns; derm; conj; cough; CNS depres; delayed pulm edema; in animals: kidney, repro, terato effects |
ACETIC ANHYDRIDE 108-24-7 |
eyes; skin; resp tract |
skin |
Inhalation: corrosive, cough, laboured breathing, shortness of breath, sore throat, symptoms may be delayed Skin: corrosive, redness, pain, blisters Eyes: corrosive, redness, pain, severe deep burns Ingestion: corrosive, abdominal pain, sore throat, collapse |
Resp sys; skin; eyes Inh; con |
Conj, lac, corn edema, opac, photo; nasal, phar irrit; cough, dysp, bron; skin burns, vesic, sens derm |
ACETYLSALICYLIC ACID 50-78-2 |
eyes; skin; resp tract |
liver; kidneys; bladder; GI tract; CVS; CNS; resp tract |
Inhalation: cough, dullness Skin: redness Eyes: redness |
Eyes; skin; resp sys; blood; liver; kidney Inh; ing; con |
Irrit eyes, skin, upper resp sys; incr blood clotting time; nau, vomit; liver, kidney inj |
ACRYLIC ACID 79-10-7 |
eyes; skin; resp tract; lungs |
Inhalation: burning sensation, cough, nasal discharge, laboured breathing, sore throat Skin: may be absorbed, redness, pain, blisters Eyes: redness, pain, loss of vision, severe deep burns Ingestion: severe burns to lips, mouth and throat, abdominal cramps, diarrhoea, unconsciousness, shock |
Eyes, skin, resp sys Inh; abs; ing; con |
Irrit eyes, skin, resp sys; eye, skin burns; skin sens; in animals: lung, liver, kidney inj |
|
ADIPIC ACID 124-04-9 |
eyes; skin; resp tract |
skin |
Inhalation: cough, laboured breathing, sore throat Skin: redness Eyes: redness, pain |
||
L-ASCORBIC ACID 50-81-7 |
eyes; resp tract |
Inhalation: cough Eyes: redness Ingestion: only in case of large amount ingested: diarrhoea, vomiting |
|||
BENZOIC ACID 65-85-0 |
eyes; skin; resp tract |
skin |
Inhalation: cough, irritant Skin: redness, irritant Eyes: redness, irritant, pain Ingestion: abdominal pain, nausea, vomiting |
||
n-CAPROIC ACID 142-62-1 |
eyes; skin; resp tract |
skin |
Inhalation: cough, sore throat Skin: may be absorbed, redness, burning sensation, pain Eyes: redness, pain, blurred vision Ingestion: abdominal pain, nausea, sore throat, vomiting |
||
CHLOROACETIC ACID 79-11-8 |
Inhalation: corrosive, burning sensation, cough, laboured breathing, sore throat, symptoms may be delayed Skin: corrosive, may be absorbed, redness, pain, blisters Eyes: redness, pain, severe deep burns Ingestion: abdominal cramps, burning sensation, collapse |
||||
CITRIC ACID 77-92-9 |
eyes; skin; resp tract |
Inhalation: burning sensation, cough, laboured breathing Skin: redness Eyes: redness, pain Ingestion: cough |
|||
CITRIC ACID HYDRATE 5949-29-1 |
eyes; resp tract |
Inhalation: cough, sore throat Skin: redness Eyes: redness, pain Ingestion: sore throat, mild burning sensation |
|||
CROTONIC ACID 3724-65-0 |
eyes; skin; resp tract; lungs |
skin |
Inhalation: burning sensation, cough, headache, nausea, shortness of breath, sore throat, symptoms may be delayed Skin: skin burns, burning sensation, pain Eyes: pain, blurred vision, severe deep burns Ingestion: pain, burning sensation, diarrhoea, sore throat, vomiting |
||
DICHLOROACETIC ACID 79-43-6 |
eyes; skin; resp tract; lungs |
Inhalation: burning sensation, cough, laboured breathing, unconsciousness, symptoms may be delayed Skin: redness, pain, blisters Eyes: redness, pain, severe deep burns Ingestion: abdominal cramps, burning sensation, sore throat, unconsciousness, vomiting, weakness |
|||
2,4-DICHLOROPHENOXYACETIC ACID 94-75-7 |
eyes; skin; resp tract |
Inhalation: headache, nausea, weakness Skin: redness Eyes: redness Ingestion: abdominal pain, burning sensation, diarrhoea, headache, nausea, unconsciousness, vomiting, weakness |
Skin; CNS; liver; kidneys Inh; abs; ing; con |
Weak, stupor, hyporeflexia, musc twitch; convuls; derm; in animals: liver, kidney inj |
|
ETHANEDIOIC ACID, DIHYDRATE 6153-56-6 |
eyes; skin; resp tract; lungs; kidneys |
kidneys |
Inhalation: cough, shortness of breath, sore throat Skin: may be absorbed, dry skin, redness, skin burns, pain, blisters Eyes: redness, pain, severe deep burns Ingestion: abdominal cramps, sore throat, vomiting, weakness, convulsions |
||
2-ETHYLHEXANOIC ACID 149-57-5 |
eyes; skin; resp tract |
liver |
Skin: rednessEyes: redness, pain |
||
FLUOROACETIC ACID 144-49-0 |
eyes; skin; resp tract; CVS; CNS; kidneys |
||||
FORMIC ACID 64-18-6 |
eyes; skin; resp tract; lungs |
skin |
Inhalation: burning sensation, cough, laboured breathing, shortness of breath, symptoms may be delayed Skin: redness, serious skin burns, pain Eyes: redness, pain, blurred vision, severe deep burns Ingestion: abdominal pain, burning sensation, diarrhoea, sore throat, vomiting |
Eyes; skin; resp sys Inh; ing; con |
Irrit eyes, skin, throat; skin burns; derm; lac; rhin; cough, dysp; nau |
LACTIC ACID 598-82-3 |
eyes; skin; resp tract |
Inhalation: cough, shortness of breath, sore throat, symptoms may be delayed Skin: redness, skin burns, pain Eyes: redness, pain, severe deep burns Ingestion: abdominal pain, burning sensation, nausea, sore throat, vomiting |
|||
MALEIC ACID 110-16-7 |
eyes; skin; resp tract |
skin; kidneys |
Inhalation: cough, laboured breathing Skin: redness, skin burns, severe irritant Eyes: redness, pain, blurred vision Ingestion: burning sensation, see inhalation , |
||
MALEIC ANHYDRIDE 108-31-6 |
eyes; skin; resp tract |
skin |
Inhalation: cough, headache, laboured breathing, nausea, shortness of breath, vomiting Skin: redness, skin burns Eyes: redness, pain, lacrymation, severe deep burns Ingestion: abdominal pain |
Eyes; skin; resp sys Inh; ing; con |
Irrit nose, upper resp sys; conj; photo, double vision; bronchial asthma; derm |
METHACRYLIC ACID 79-41-4 |
eyes; skin; mucous membranes; resp tract; lungs |
Inhalation: burning sensation, cough, laboured breathing Skin: redness, skin burns, pain, blisters Eyes: redness, pain, loss of vision, severe deep burns Ingestion: abdominal cramps, abdominal pain, burning sensation, weakness |
Eyes; skin; resp sys Inh; abs; ing; con |
Irrit eyes, skin, muc memb; eye, skin burns |
|
2-METHYL-4-CHLOROPHENOACETIC ACID 94-74-6 |
eyes; skin; resp tract |
birth defects |
Inhalation: headache, nausea Skin: redness Eyes: redness Ingestion: abdominal pain, nausea, unconsciousness, vomiting, weakness |
||
OXALIC ACID 144-62-7 |
eyes; skin; resp tract; lungs; kidneys |
skin; kidneys |
Inhalation: burning sensation, cough, laboured breathing, sore throat, symptoms may be delayed Skin: redness, skin burns, pain, blisters Eyes: redness, pain, blurred vision, loss of vision, severe deep burns Ingestion: burning sensation, drowsiness, sore throat, vomiting, shock, low back pain |
Resp sys; skin; kidneys; eyes Inh; ing; con |
Irrit eyes, skin, muc memb; eye burns; local pain, cyan; shock, collapse, convuls; kidney damage |
PALMITIC ACID 57-10-3 |
eyes; skin; resp tract; lungs |
skin |
Eyes: redness |
||
PHTHALIC ANHYDRIDE 85-44-9 |
eyes; skin; resp tract |
skin; lungs |
Resp sys; eyes; skin; liver; kidneys Inh; ing; con |
Irrit eyes, skin, upper resp sys; conj; nasal ulcer bleeding; bron, bronchial asthma; derm; in animals: liver, kidney damage |
|
PHTHALIC ACID 88-99-3 |
eyes; skin; resp tract |
Inhalation: cough Skin: redness Eyes: redness, pain |
|||
PROPIONIC ACID 79-09-4 |
eyes; skin; resp tract |
Inhalation: cough, laboured breathing, sore throat Skin: skin burns, pain, blisters Eyes: redness, pain, blurred vision, severe deep burns Ingestion: abdominal pain, nausea, sore throat, vomiting, |
Eyes; skin; resp sys Inh; abs; ing; con |
Irrit eyes, skin, nose, throat; blurred vision, com burns; skin burns; abdom pain, nau, vomit |
|
PROPIONIC ANHYDRIDE 123-62-6 |
eyes; skin; resp tract; lungs |
Inhalation: burning sensation, cough, laboured breathing, sore throat, symptoms may be delayed Skin: redness, skin burns Eyes: redness, severe deep burns Ingestion: sore throat, burns |
|||
SALICYLIC ACID 69-72-7 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: cough, sore throat Skin: may be absorbed, redness, pain Eyes: redness, pain, blurred vision Ingestion: nausea, vomiting, ear ringing |
||
STEARIC ACID 57-11-4 |
eyes |
lungs |
Inhalation: cough, laboured breathing Eyes: redness, pain Ingestion: constipation |
||
SULPHANILIC ACID 121-57-3 |
eyes; skin; resp tract; blood |
skin; lungs |
Inhalation: blue lips or finger nails, blue skin, cough, dizziness, headache, laboured breathing, sore throat Skin: redness Eyes: redness Ingestion: blue lips or fingernails, blue skin, dizziness, headache, laboured breathing |
||
TEREPHTHALIC ACID 100-21-0 |
eyes; skin |
Inhalation: cough, irritant Skin: redness, mild irritant Eyes: redness, irritant |
|||
p-TOLUENESULPHONIC ACID 104-15-4 |
eyes; skin; resp tract; lungs |
Inhalation: burning sensation, cough, laboured breathing Skin: redness, pain, blisters Eyes: redness, pain, blurred vision Ingestion: burning sensation, sore throat |
|||
2,4,5-TRICHLOROPHENOXYACETIC ACID 93-76-5 |
eyes; skin; resp tract |
Skin; liver; GI tract Inh; ing; con |
In animals: ataxia; skin irrit, acne-like rash, liver damage |
||
TRIMELLITIC ANHYDRIDE 552-30-7 |
eyes; skin; resp tract; lungs; blood |
Inhalation: cough, dizziness, wheezing, chills Skin: redness Eyes: redness, pain |
Eyes; skin; resp sys abs |
Irrit eyes, skin; nose; resp sys; pulm edema, resp sens; rhinitis, asthma, cough, wheez, dysp, mal, fever, musc aches, sneez |
|
VALERIC ACID 109-52-4 |
eyes; skin; resp tract; lungs; CNS |
Chemical Name CAS-Number |
Physical |
Chemical |
UN Class or Division / Subsidiary Risks |
ACETIC ACID |
The substance is a medium strong acid • Reacts violently with oxidants such as chromium trioxide and potassium permanganate • Reacts violently with strong bases • Attacks many metals forming combustible gas |
8 |
|
ACETIC ANHYDRIDE |
The substance decomposes on heating producing toxic fumes and gases including acetic acid • Reacts violently with boiling water, steam, strong oxidants, alcohols, amines, strong bases, and many other compounds • Attacks many metals in presence of water • The liquid is very corrosive, especially in presence of water or moisture |
8/ 3 |
|
ACETYLSALICYLIC ACID |
Dust explosion possible if in powder or granular form, mixed with air |
The substance decomposes on contact with hot water or when dissolved in solutions of alkali hydroxides and carbonates • Upon heating, toxic fumes are formed • Reacts with strong oxidants, strong acids, strong bases |
|
ACRYLIC ACID |
The vapour is heavier than air • Vapour forms explosive mixture with air |
The substance polymerizes readily due to heating, under the influence of light, oxygen, oxidizing agents such as peroxides or other activators (acid, iron salts), with fire or explosion hazard • Upon heating, toxic fumes are formed • The substance is a medium strong acid • Reacts violently with oxidants causing fire and explosion hazard • Reacts violently with strong bases and amines • Attacks many metals, including nickel and copper |
8/ 3 |
ADIPIC ACID |
Dust explosion possible if in powder or granular form, mixed with air • If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. |
The substance decomposes on heating producing volatile acidic vapours of valeric acid and other substances • The substance is a weak acid • Reacts with oxidizing materials |
|
L-ASCORBIC ACID |
The solution in water is a medium strong acid • Attacks many metals in presence of water |
||
BENZOIC ACID |
Dust explosion possible if in powder or granular form, mixed with air |
The solution in water is a weak acid • Reacts with oxidants |
|
BUTYRIC ACID |
8 |
||
n-CAPROIC ACID |
May explode on heating • On combustion, forms toxic/irritant gases • The substance is a medium strong acid • Reacts violently with oxidants (for instance chromium trioxide) causing fire and explosion hazard • Reacts vigorously with bases causing heat and pressure rise hazard • Attacks many metals forming combustible gas |
8 |
|
CHLOROACETIC ACID |
The substance decomposes on heating producing toxic and corrosive gases (hydrogen chloride, phosgene) • The solution in water is a strong acid, it reacts violently with bases and is corrosive |
6.1/ 8 |
|
CITRIC ACID |
Dust explosion possible if in powder or granular form, mixed with air |
Reacts with oxidants, reductants, bases |
|
CITRIC ACID HYDRATE |
The solution in water is a medium strong acid • Reacts violently with metal nitrates • Reacts with strong bases and oxidants • The substance will corrode copper, zinc, aluminium, and their alloys |
||
CROTONIC ACID |
The substance may polymerize under the influence of UV-light or moisture • The solution in water is a weak acid • Reacts violently with bases, oxidants, reducing agents, causing fire and explosion hazard |
8 |
|
DICHLOROACETIC ACID |
The substance decomposes on heating producing toxic and corrosive fumes (phosgene, hydrogen chloride) • The substance is a medium strong acid • Attacks many metals forming flammable hydrogen gas • Attacks rubber |
8 |
|
2,4-DICHLOROPHENOXY ACETIC ACID |
The substance decomposes on heating producing hydrogen chloride and phosgene • The substance is a weak acid • Reacts with strong oxidants causing fire and explosion hazard |
||
ETHANEDIOIC ACID, DIHYDRATE |
The substance decomposes on rapid heating above about 150°C producing toxic gas • The solution in water is a medium strong acid which reacts violently with strong bases • Reacts violently with oxidants causing fire and explosion hazard • Reacts with silver, forming explosive products |
||
2-ETHYL HEXANOIC ACID |
As a result of flow, agitation, etc, electrostatic charges can be generated • Vapour mixes readily with air |
The substance is a strong reducing agent and reacts with oxidants • Reacts with strong oxidants |
|
FLUOROACETIC ACID |
6.1 |
||
FORMIC ACID |
The substance decomposes on heating producing carbon monoxide • The substance is a medium strong acid • Reacts violently with oxidants • Reacts violently with strong bases causing fire and explosion hazard • Attacks many metals in presence of water • Attacks many plastics |
8 |
|
ISOBUTYRIC ACID |
3/ 8 |
||
LACTIC ACID |
The substance is a medium strong acid • Attacks many metals in presence of water |
||
MALEIC ACID |
On combustion, forms irritating smoke (maleic anhydride) • The substance decomposes on heating and on burning producing highly irritating fumes (maleic anhydride) • The solution in water is a medium strong acid |
||
MALEIC ANHYDRIDE |
The solution in water is a strong acid, it reacts violently with bases and is corrosive • Reacts with strong oxidants |
8 |
|
METHACRYLIC ACID |
The substance polymerizes easily due to heating or under the presence of light, oxygen, oxidizing agents such as peroxides, or in the presence of traces of hydrochloric acid, with fire or explosion hazard • The substance decomposes on heating producing acrid fumes • The substance is a strong reducing agent and reacts with oxidants • The substance is a medium strong acid • Attacks metals |
8 |
|
2-METHYL-4-CHLOROPHENOACETIC ACID |
The substance decomposes on heating producing toxic and corrosive fumes including hydrogen chloride • The substance is a weak acid |
||
OXALIC ACID |
On contact with hot surfaces or flames this substance decomposes forming formic acid and carbon monoxide • The substance is a strong reducing agent and reacts with oxidants • The solution in water is a medium strong acid • Reacts violently with strong oxidants causing fire and explosion hazard • Reacts with some silver compounds to form explosive silver oxalate |
||
PALMITIC ACID |
On heating forms carbon oxides • The substance is a weak acid • Reacts with bases, oxidants, and reducing agents |
||
PHTALIC ANHYDRIDE |
8 |
||
PHTHALIC ACID |
The solution in water is a medium strong acid |
||
PROPIONIC ACID |
The substance is a medium strong acid • Reacts with oxidants • Attacks many metals in presence of water |
8 |
|
PROPIONIC ANHYDRIDE |
The vapour is heavier than air |
On combustion, forms toxic gases • Reacts with oxidants, bases and water |
8 |
SALICYLIC ACID |
Dust explosion possible if in powder or granular form, mixed with air |
The substance decomposes on heating producing phenol vapours • The substance is a medium strong acid • Reacts violently with strong bases and strong oxidants |
|
STEARIC ACID |
The substance decomposes on heating producing carbon oxides • The substance is a weak acid • Reacts with bases, oxidants and reducing agents |
||
SULPHANILIC ACID |
On combustion, forms toxic gases of carbon, nitrogen and sulphur oxides • The substance decomposes on heating • Reacts with oxidants |
||
TEREPHTHALIC ACID |
Dust explosion possible if in powder or granular form, mixed with air |
Reacts violently with strong oxidants |
|
p-TOLUENESULFONIC ACID |
The substance decomposes on burning producing carbon oxides and sulphur oxides • The substance is a strong acid, it reacts violently with bases and is corrosive • Attacks many metals forming extremely flammable gas |
||
2,4,5-TRICHLOROPHENOXYACETIC ACID |
6.1 |
||
TRIFLUOROACETIC ACID |
8 |
||
TRIMELLITIC ANHYDRIDE |
Dust explosion possible if in powder or granular form, mixed with air • If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc |
Reacts violently with oxidants • Reacts slowly with water to form trimellitic acid |
For UN Class: 1.5 = very insensitive substances which have a mass explosion hazard; 2.1 = flammable gas; 2.3 = toxic gas; 3 = flammable liquid; 4.1 = flammable solid; 4.2 = substance liable to spontaneous combustion; 4.3 = substance which in contact with water emits flammable gases; 5.1 = oxidizing substance; 6.1 = toxic; 7 = radioactive; 8 = corrosive substance.
Chemical Name |
Colour/Form |
Boiling Point (ºC) |
Melting Point (ºC) |
Molecular Weight |
Solubility in Water |
Relative Density (water=1) |
Relative Vapour Density (air=1) |
Vapour Pressure/ (Kpa) |
Inflam. |
Flash Point (ºC) |
Auto Ignition Point (ºC) |
ACETIC ACID |
rhombic crystals (<16.6 ºC melting point); colourless liquid (16.6 ºC melting point) |
118 |
16.6 |
60.05 |
misc |
1.0492 |
2.1 |
1.6 |
4 ll |
39 cc |
426 |
ACETIC ANHYDRIDE |
colourless, very mobile, strongly refractive liquid |
139 |
-73 |
102.10 |
v sol |
@ 15 ºC |
3.5 |
0.5 |
2.9 ll |
49 cc |
316 |
ACETYLSALICYLIC ACID |
monoclinic tablets or needle-like crystals |
135 |
180.15 |
sl sol |
1.40 |
@ 25 ºC |
|||||
ACRYLIC ACID |
colourless liquid |
141 |
14 |
72.06 |
misc |
1.0511 |
2.5 |
0.413 |
2.9 ll |
54 oc |
360 |
ADIPIC ACID |
monoclinic prisms from ethyl acetate, water, or acetone and petroleum ether; fine white crystals or powder |
337.5 |
152 |
146.14 |
sl sol |
@ 25 ºC/4 ºC |
5.04 |
@ 18.5 ºC |
10 ll |
196 cc |
422 |
L-ASCORBIC ACID |
crystals (usually plates, sometimes needles, monoclinic system); white to slightly yellow crystals or powder |
190-192 |
176.12 |
v sol |
@ 25 ºC |
||||||
BENZOIC ACID |
monoclinic tablets, plates, leaflets; white scales or needle crystals |
249.2 |
122.4 |
122.13 |
@ 20 ºC |
@ 15 ºC/4 ºC |
4.21 |
@ 96 ºC |
121 cc |
570 |
|
BUTYRIC ACID |
oily liquid; colourless liquid |
165.5 |
-7.9 |
88.10 |
misc |
0.9577 |
3.0 |
0.43 mm Hg |
2.0 ll |
72 cc |
443 |
BUTYRYL CHLORIDE |
colourless liquid |
101-102 |
-89 |
106.55 |
slowly with decomposition |
@ 20.6 ºC/4 ºC |
< 21 |
||||
n-CAPROIC ACID |
oily liquid |
205.8 |
-3.4 |
116.16 |
insol |
0.929 |
4.01 |
0.024 |
1.3 ll |
102 oc |
380 |
CHLORENDIC ACID |
crystalline solid |
388.84 |
|||||||||
CHLOROACETIC ACID |
monoclinic prisms; colourless or white crystals; colourless to light-brownish crystals |
189 |
(alpha) 63 ; (beta) 55-56 ; (gamma) 50 |
94.50 |
v sol |
1.6 |
3.26 |
@ 43 ºC |
8.0 ll |
126 |
>500 |
o-CHLOROBENZOIC ACID |
monoclinic prisms from water |
sublimes |
142 |
156.6 |
sol |
1.544 |
@ 25 ºC |
||||
m-CHLOROBENZOIC ACID |
crystals; prisms from water |
sublimes |
158 |
156.6 |
v sol |
@ 25 ºC/4 ºC |
@ 25 ºC |
||||
p-CHLOROBENZOIC ACID |
triclinic prisms from alcohol and ether; nearly white coarse powder |
243 |
156.6 |
insol |
@ 25 ºC |
||||||
2-CHLOROPROPIONIC ACID |
crystals |
186 |
-12.1 |
108.53 |
misc |
1.2585 |
|||||
CITRIC ACID |
crystals/monoclinic holohedra/crystallize from hot concentrated aq soln; colourless, translucent crystals or white, granular to fine crystalline powder/ rhombic crystals from water with 1 mol of water of crystallization |
decomp |
153 |
192.12 |
v sol |
1.665 |
0.28 ll |
||||
CITRIC ACID HYDRATE |
crystals |
decomp |
100 |
sol |
1.5 |
0.28 ll |
1010 |
||||
CROTONIC ACID |
monoclinic needles or prisms (from water or petroleum ether); colourless needle-like crystals; white crystalline solid |
185 |
71.5-71.7 |
86.09 |
v sol |
@ 15 ºC/4 ºC; 0.964 |
2.97 |
0.024 |
88 |
396 |
|
DICHLOROACETIC ACID |
colourless liquid |
194 |
9.7 |
128.94 |
misc |
1.56 |
4.45 |
0.019 |
|||
2,4-DICHLOROPHENOXYACETIC ACID |
white to yellow crystalline powder; yellow colour is phenolic impurities; colourless powder; white |
@ 0.4 mm Hg |
138 |
221.04 |
insol |
1.6 |
7.6 |
@ 160 ºC |
88 oc |
||
2,4-DICHLOROPHENOXYPROPIONIC ACID |
colourless crystalline solid; white to tan, crystalline solid |
117.5-118.1 |
235.07 |
1.42 |
|||||||
ETHANEDIOIC ACID, DIHYDRATE |
colourless crystals |
sublimes |
102 |
10g/100 ml |
1.7 |
3.1 |
|||||
2-ETHYLHEXANOIC ACID |
colourless liquid |
228 |
- 59 |
144.2 |
sol |
@ 25 ºC/4 ºC |
5.0 |
0.004 |
0.8 ll |
118 oc |
310 |
FLUOROACETIC ACID |
needles; colourless crystals |
165 |
35.2 |
78.04 |
sol |
@ 36 ºC |
@ 25 ºC |
||||
FORMIC ACID |
colourless liquid |
101 |
8.4 |
46.00 |
misc |
1.22 |
1.6 |
4.4 |
14 ll |
69 |
480-520 |
FUMARIC ACID |
needles, monoclinic prisms or leaflets from water; colourless crystals; white crystalline powder |
@ 1.7 mm Hg |
300-302 |
116.07 |
sl sol |
1.635 |
|||||
GALLIC ACID |
prisms from water; needles from absolute methanol or chloroform |
253 |
170.1 |
sl sol |
@ 6 ºC/4 ºC |
||||||
GLYCOLIC ACID |
colourless crystals; rhombic needles from water; leaves from ethanol |
100 |
80 |
76.05 |
sol |
||||||
HEPTANOIC ACID |
clear oily liquid |
223.01 |
-7.5 |
130.2 |
sl sol |
0.92 |
|||||
ISOBUTYRIC ACID |
colourless liquid |
152-155 |
-47 |
88.1 |
v sol |
0.950 |
3.0 |
@ 14.7 ºC |
|||
ISOPHTHALIC ACID |
needles |
sublimes |
347 |
166.13 |
sl sol |
||||||
LACTIC ACID |
colourless liquid or colourless crystals |
16.8-18 |
90.08 |
v sol |
>74 |
||||||
LAURIC ACID |
colourless solid; white, crystalline powder |
298.9 |
44.2 |
200.3 |
insol |
0.883 |
@ 121.0 ºC |
||||
MALEIC ACID |
monoclinic prisms from water; white crystals from water, alcohol & benzene; colourless crystals |
135 |
138-139 |
116.07 |
@ 25 ºC |
1.590 |
4.0 |
||||
MALEIC ANHYDRIDE |
orthorhombic needles from chloroform; commercial grades in fused form, as briquettes; colourless needles or white lumps or pellets; needles from chloroform or ether |
202.0 |
52.8 |
98.06 |
sol |
1.48 |
3.4 |
@ 25 ºC |
1.4 ll |
102 |
475 |
MALONIC ACID |
white crystals |
decomp |
132- 134 |
104.06 |
sol |
1.63 |
|||||
METHACRYLIC ACID |
liquid or colourless crystals; colourless liquid |
163 |
16 |
86.09 |
sol |
1.0153 |
2.97 |
@ 25 ºC |
77 oc |
||
2-METHYL-4-CHLOROPHENOACETIC ACID |
light brown solid; plates from benzene or toluene; white crystalline solid (pure compd); colourless crystalline solid (pure) |
120 |
200.6 |
sl sol |
@ 25 ºC/15.5 ºC |
6.9 |
0.0002 Pa |
||||
METHACRYLIC ACID, 2-DIMETHYLAMINOETHYL |
liquid |
62-65 |
-30 |
157.22 |
sol |
@ 25 ºC/5 ºC |
5.4 |
739 oc |
|||
NONANOIC ACID |
colourless, oily liquid at ordinary temp; crystallizes when cooled; yellowish oil |
255 |
12.5 |
158.23 |
insol |
0.9057 |
|||||
OLEIC ACID |
colourless or nearly colourless liquid (above 5-7 ºC); yellowish, oily liquid; water-white liquid |
@ 100 mm Hg |
16.3 |
282.45 |
insol |
@ 25 ºC |
363 |
||||
OXALIC ACID |
anhyd oxalic acid, crystallized from glacial acetic acid is orthorhombic, crystals being pyramidal or elongated octahedra; transparent, colourless crystals or white powder |
157 |
189.5 |
90.04 |
sol |
@ 17 ºC /4 ºC |
|||||
PALMITIC ACID |
white crystalline scales; needles from alcohol |
@ 15 mm Hg |
63-64 |
256.5 |
insol |
@ 62 ºC/4 ºC |
@ 154 ºC |
||||
PHTHALIC ACID |
crystals; plates from water |
decomp |
210-211 |
166.13 |
sl sol |
1.59 |
5.73 |
168 oc |
|||
PHTHALIC ANHYDRIDE |
white, lustrous needles; colourless or pale yellow solid flakes; colourless needles; monoclinic or rhombic prisms; white needles from alcohol and benzene |
295 |
130.8 |
148.11 |
sl sol |
1.527 |
5.1 |
0.27 Pa |
1.7 ll |
570 |
|
PIVALIC ACID |
coloured crystals |
164 |
35.5 |
102.13 |
sl sol |
@ 50 ºC |
|||||
PROPIONIC ANHYDRIDE |
colourless liquid |
167 |
-45 |
130.2 |
decomposes |
1.01 |
4.5 |
100 |
1.3 ll |
63 |
285 |
PROPIONIC ACID |
colourless liquid; oily liquid |
141 |
-20.8 |
74.09 |
misc |
0.9930 |
2.56 |
0.386 |
2.9 ll |
544 |
955 |
SALICYLIC ACID |
white, fine, needle-like crystals, or fluffy, white crystalline powder; needles in water; monoclinic prisms in alcohol |
211 |
158 |
138.12 |
sl sol |
1.443 |
4.8 |
0.114 |
1.1 ll |
157 |
540 |
STEARIC ACID |
monoclinic leaf from alcohol; white or slightly yellow, crystal masses or powder |
@ 15 mm Hg |
69 |
284.50 |
insol |
0.9408 |
9.80 |
@ 173.7 ºC |
196 |
395 |
|
SUCCINIC ACID |
white minute monoclinic prisms; triclinic or monoclinic prisms |
235 |
188 |
118.09 |
sl sol |
@ 25 ºC/4 ºC |
|||||
SULPHANILIC ACID |
rhombic plates or monoclinic crystals from water |
288 |
173.2 |
sl sol |
@ 25 ºC/4 ºC |
||||||
TARTARIC ACID |
169 |
150.08 |
|||||||||
TEREPHTHALIC ACID |
needles; white crystals or powder |
402 |
166.13 |
insol |
1.51 |
< 0.001 |
260 |
496 |
|||
p-tert BUTYLBENZOIC ACID |
needles from dilute alcohol |
164.5-165.5 |
178.2 |
insol |
|||||||
p-TOLUENESULPHONIC ACID |
monoclinic leaflets or prisms; colourless crystals |
140 |
106-107 |
172.2 |
v sol |
1.24 |
184 cc |
||||
TRICHLOROACETIC ACID |
crystals; colourless; white solid |
197.55 |
58 |
163.40 |
v sol |
@ 25 C/4 ºC |
@ 51.0 ºC |
||||
2,4,5-TRICHLOROPHENOXYACETIC ACID |
white solid; light tan solid |
decomp |
153 |
255.5 |
insol |
1.80 |
< 0.01 mPa |
||||
TRIFLUOROACETIC ACID |
colourless, fuming liquid |
73 |
-15.2 |
114.02 |
sol |
@ 25 ºC |
|||||
TRIMELLITIC ANHYDRIDE |
crystals; colourless solid |
240-245 |
161-163.5 |
192.13 |
reacts |
6.6 |
@ 25 ºC |
1 ll |
|||
VALERIC ACID |
colourless liquid |
186-187 |
-34.5 |
102.15 |
sol |
0.939 |
3.5 |
0.020 |
96 oc |
400 |
Chemical Formula |
Chemical |
Synonyms |
CAS-Number |
107186 |
ALLYL ALCOHOL |
Allylic alcohol; |
107-18-6 |
100516 |
BENZYL ALCOHOL |
Benzenecarbinol; |
100-51-6 |
71363 |
BUTYL ALCOHOL |
n-Butanol; |
71-36-3 |
78922 |
sec-BUTYL ALCOHOL |
2-Butanol; |
78-92-2 |
75650 |
tert-BUTYL ALCOHOL |
tert-Butanol; |
75-65-0 |
108930 |
CYCLOHEXANOL |
Cyclohexyl alcohol; |
108-93-0 |
107073 |
2-CHLOROETHANOL |
Ethylene chlorohydrin; |
107-07-3 |
96231 |
1,3-DICHLORO-2-PROPANOL |
Dichlorohydrin; |
96-23-1 |
1185337 |
2,2-DIMETHYL-1-BUTANOL |
2,2,-Dimethylbutanol |
1185-33-7 |
108827 |
2,6-DIMETHYL-4-HEPTANOL |
Diisobutyl carbinol; |
108-82-7 |
ETHANOL |
Ethyl alcohol; |
64-17-54175 |
|
97950 |
2-ETHYLBUTYL ALCOHOL |
2-Ethylbutanol; |
97-95-0 |
104767 |
2-ETHYL-1-HEXANOL |
Ethylhexanol; |
104-76-7 |
111706 |
HEPTANOL |
1-Heptanol; |
111-70-6 |
543497 |
2-HEPTANOL |
Amyl methyl carbinol; |
543-49-7 |
111273 |
HEXANOL |
1-Hexanol; |
111-27-3 |
123513 |
ISOAMYL ALCOHOL |
Isobutylcarbinol; |
123-51-3 |
78831 |
ISOBUTYL ALCOHOL |
Isobutanol; |
78-83-1 |
25339177 |
ISODECYL ALCOHOL |
Isodecanol |
25339-17-7 |
26952216 |
ISOOCTYL ALCOHOL |
Isooctanol |
26952-21-6 |
67630 |
ISOPROPYL ALCOHOL |
Dimethylcarbinol; |
67-63-0 |
67561 |
METHANOL |
Methyl alcohol; |
67-56-1 |
137326 |
2-METHYL-1-BUTANOL |
D,L-sec-Butyl carbinol; |
137-32-6 |
25639423 |
METHYLCYCLOHEXANOL |
Hexahydrocresol; |
25639-42-3 |
583595 |
o-METHYL CYCLOHEXANOL |
583-59-5 |
|
591231 |
m-METHYLCYCLOHEXANOL |
591-23-1 |
|
108112 |
2-METHYL-4-PENTANOL |
Isobutylmethylcarbinol; |
108-11-2 |
143088 |
NONANOL |
n-Nonyl-alcohol; |
143-08-8 |
OCTANOL |
Octyl alcohol; |
111-87-511875 |
|
123966 |
2-OCTANOL |
Capryl alcohol |
123-96-6 |
143282 |
OLEYL ALCOHOL |
Oleol; |
143-28-2 |
71410 |
1-PENTANOL |
Amyl alcohol; |
71-41-0 |
584021 |
3-PENTANOL |
584-02-1 |
|
75854 |
tert-PENTYL ALCOHOL |
tert-Amyl alcohol; |
75-85-4 |
60128 |
PHENYLETHANOL |
Benzyl carbinol; |
60-12-8 |
71238 |
PROPANOL |
Ethyl carbinol; |
71-23-8 |
107197 |
PROPARGYL ALCOHOL |
Ethynylcarbinol; |
107-19-7 |
97994 |
TETRAHYDROFURFURYL ALCOHOL |
Tetrahydro-2-furancarbinol ; |
97-99-4 |
112709 |
TRIDECANOL |
Tridecyl alcohol |
112-70-9 |
Chemical name CAS-Number |
ICSC Short-Term Exposure |
ICSC Long-Term Exposure |
Routes of Exposure and Symptoms |
US NIOSH Target Organs & Routes of Entry |
US NIOSH Symptoms |
ALLYL ALCOHOL 107-18-6 |
eyes; skin; resp tract; muscles; liver; kidneys |
Inhalation: headache, nausea, vomiting Skin: may be absorbed, aching, pain, blisters Eyes: redness, pain, blurred vision, temporary loss of vision, severe deep burns, sensitivity to light Ingestion: abdominal pain, unconsciousness |
Eyes; skin; resp sysInh, abs, ing, con |
Eye irrit, tissue damage; irrit upper resp sys, skin; pulm edema |
|
BENZYL ALCOHOL 100-51-6 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: cough, sore throat Skin: redness Eyes: redness Ingestion: abdominal pain, diarrhoea, drowsiness, nausea, vomiting |
||
BUTYL ALCOHOL 71-36-3 |
Skin; eyes; resp sys; CNSInh, abs, ing, con |
Irrit eyes, nose, throat; head, verti, drow; corn inflamm, blurred vision, lac, photo; derm; possible auditory nerve damage, hearing loss; CNS depres |
|||
sec-BUTYL ALCOHOL 78-92-2 |
Eyes; skin, resp sys; CNSInh, ing, con |
Irrit eyes, skin, throat, nose; narco |
|||
tert-BUTYL ALCOHOL 75-65-0 |
Eyes; skin, resp sys, CNSInh, ing, con |
Irrit eyes, skin, nose, throat; head; skin flush, burns |
|||
2-CHLOROETHANOL 107-07-3 |
eyes; respiratory tract; CNS; cardiovascular system; kidneys; liver; may result in death |
Inhalation: Mucous membranes, nausea Skin: Vomiting, vertigo, incoordination Ingestion: Numbness, visual distortion, headache |
Resp sys; liver; kidneys; CNS; skin; CVS; eyesInh, abs, ing, con |
Irrit muc memb; nau, vomit; verti, inco; numb; vis dist; head; thirst; delirium; low BP; collapse, shock, coma; liver, kidney damage |
|
CYCLOHEXANOL 108-93-0 |
eyes; skin; resp tract; CNS |
skin |
Eyes; resp sys; skinInh, abs, ing, con |
Irrit eyes, skin, nose, throat; skin; narco |
|
ETHANOL 64-17-5 |
eyes; skin; resp tract; CNS |
skin; CNS; liver; blood |
Inhalation: cough, drowsiness, headache, fatigue Skin: dry skin Eyes: redness, irritant pain, irritant burning Ingestion: burning sensation, confusion, dizziness, headache, unconsciousness |
Eyes; skin; resp sys; CNS; liver; blood; repro sysInh, ing, con |
Irrit eyes, skin, nose; head, drow, ftg, narco; cough; liver damage; anemia; repro, terato effects |
2-ETHYL-1-HEXANOL 104-76-7 |
eyes; skin |
Inhalation: dizziness, headache, nausea, weakness Skin: may be absorbed, redness Eyes: redness, pain |
|||
HEPTANOL 111-70-6 |
eyes; skin; resp tract |
liver; kidneys; birth defects |
|||
HEXANOL 626-93-7 |
eyes; skin; resp tract; CNS |
skin; CNS |
Inhalation: cough, headache, sore throat Skin: may be absorbed, redness Eyes: redness, pain Ingestion: abdominal pain, dizziness, drowsiness, headache, nausea |
||
ISOAMYL ALCOHOL 123-51-3 |
eyes; resp tract; CNS |
skin |
Inhalation: cough, dizziness, drowsiness, headache, nausea, sore throat Skin: dry skin Eyes: redness, pain Ingestion: abdominal pain, unconsciousness |
Eyes; skin; resp sys; CNSInh, ing, con |
Irrit eyes, skin, nose, throat; head, dizz; cough, dysp, nau, vomit, diarr; skin cracking; in animals: narco |
sec-ISOAMYL ALCOHOL 528-75-4 |
Eyes; skin; resp sys; CNSInh, ing, con |
Irrit eyes, skin, nose, throat; head, dizz; cough, dysp, nau, vomit, diarr; skin cracking; in animals: narco |
|||
ISOBUTYL ALCOHOL 78-83-1 |
eyes; resp tract; CNS |
skin |
Eyes; skin; resp sys; CNSInh, ing, con |
Irrit eyes, throat, head, drow; skin cracking; in animals: narco |
|
ISODECYL ALCOHOL 25339-17-7 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: dizziness, dullness, headache, nausea Skin: redness Eyes: redness, pain Ingestion: diarrhoea, nausea, vomiting |
||
ISOOCTYL ALCOHOL 26952-21-6 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: dizziness, dullness, headache, nausea Skin: may be absorbed, redness, skin burns Eyes: redness, pain Ingestion: diarrhoea, nausea, vomiting |
Eyes; skin; resp sys; CNS; CVSInh, abs, ing, con |
Irrit eyes, skin, nose throat; eye, skin burns |
ISOPROPYL ALCOHOL 67-63-0 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: cough, dizziness, drowsiness, headache, nausea, sore throat, vomiting Skin: redness Eyes: redness, pain, blurred vision Ingestion: dizziness, drowsiness, nausea, sore throat, vomiting |
Eyes; skin; resp sys; CNSInh, ing, con |
Irrit eyes, nose, throat; drow, dizz, head; dry cracking skin; in animals: narco |
METHANOL 67-56-1 |
eyes; skin; resp tract; CNS |
CNS |
Inhalation: cough, dizziness, headache, nausea Skin: may be absorbed, dry skin, redness Eyes: redness, pain Ingestion: abdominal pain, shortness of breath, unconsciousness, vomiting |
Eyes; skin, resp sys; CNS; GI tractInh, abs, ing, con |
Irrit eyes, skin, upper resp sys; head, dizz, verti, li-head, nau, vomit; vis dist, optic nerve damage (blindness); derm |
3-METHOXY 1-BUTANOL 2517-43-3 |
eyes; skin; resp tract; lungs |
skin |
Inhalation: cough, headache, symptoms may be delayed Skin: dry skin, burning sensation Eyes: redness Ingestion: abdominal pain, dullness, nausea, vomiting |
||
2-METHYL-1-BUTANOL 137-32-6 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: cough, dizziness, drowsiness, sore throat Skin: dry skin, redness Eyes: redness, pain, blurred vision |
||
METHYLCYCLOHEXANOL 25639-42-3 |
eyes; upper resp tract |
skin; CNS |
Inhalation: cough, headache Skin: dry skin, redness Eyes: redness |
Resp sys; skin; eyes; liver; kidneys; CNS Inh, abs, ing, con |
Irrit eyes, skin, upper resp sys; head; in animals: narco; liver, kidney damage |
o-METHYLCYCLOHEXANOL 583-59-5 |
eyes; upper resp tract |
skin; CNS |
Inhalation: cough, headache Skin: dry skin, redness Eyes: redness |
||
m-METHYLCYCLOHEXANOL 591-23-1 |
skin |
Inhalation: cough, headache Skin: dry skin, redness Eyes: redness |
|||
2-METHYL-4-PENTANOL 108-11-2 |
eyes; skin; resp tract; lungs; CNS; liver; kidneys |
skin; CNS; liver; kidneys |
Inhalation: confusion, drowsiness, headache, nausea, sore throat, unconsciousness Skin: may be absorbed, redness, burning sensation Eyes: redness, pain Ingestion: abdominal pain |
Eyes; skin; CNS Inh, abs, ing, con |
Irrit eyes, skin; head, drow; derm; in animals: narco |
1-PENTANOL 71-41-0 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: cough, dizziness, headache, nausea Skin: redness Eyes: redness, pain, possible corneal damage Ingestion: cough, dizziness, headache, nausea, vomiting |
||
3-PENTANOL 584-02-1 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: cough, dizziness, headache, nausea, sore throat, vomiting Skin: may be absorbed, redness Eyes: redness, pain, blurred vision Ingestion: abdominal pain, diarrhoea, nausea, vomiting |
||
2-PHENYLETHANOL 60-12-8 |
eyes; resp tract |
CNS |
Inhalation: coughEyes: redness |
||
PROPANOL 71-23-8 |
eyes; skin; resp tract; CNS |
skin |
Inhalation: cough, dizziness, drowsiness, headache, nausea, sore throat, vomiting Skin: redness Eyes: redness, pain, blurred vision Ingestion: dizziness, drowsiness, nausea, sore throat, vomiting |
Skin; eyes; resp sys; GI tract; CNS Inh, abs, ing, con |
Irrit eyes, nose, throat; dry cracking skin; drow, head; ataxia, GI pain; abdom cramps, nau, vomit, diarr; in animals: narco |
PROPARGYL ALCOHOL 107-19-7 |
eyes; skin; resp tract; liver; kidneys; blood |
Inhalation: burning sensation Skin: may be absorbed, redness Eyes: pain, severe deep burns |
Skin; resp sys; CNS; liver; kidneys Inh, abs, ing, con |
irrit skin, muc memb; CNS depres; in animals: liver, kidney damage |
|
TETRAHYDROFURFURYL ALCOHOL 97-99-4 |
Inhalation: sore throat, cough, headache, nausea, dizziness, drowsiness, unconsciousness Skin: redness, irritation, pain Eyes: redness, irritation, pain Ingestion: abdominal pain |
||||
3,5,5-TRIMETHYL-1-HEXANOL 3452-97-9 |
eyes; skin; resp tract |
liver; kidneys |
Inhalation: cough, headache, sore throat Skin: may be absorbed, roughness, burning sensation Eyes: redness, pain Ingestion: headache, nausea, vomiting |
Chemical Name CAS-Number |
Physical |
Chemical |
N Class or Division / Subsidiary Risks |
ALLYL ALCOHOL |
The vapour is heavier than air and may travel along the ground; distant ignition possible |
On combustion, forms carbon monoxide • Upon heating, toxic fumes are formed • Reacts with carbon tetrachloride, nitric acid, chlorosulphonic acid causing fire and explosion hazard |
6.1/ 3 |
BENZYL ALCOHOL |
Reacts violently with strong oxidants and acids • Attacks many plastics • Can attack iron, aluminium upon heating • Slow oxidation in the presence of air |
||
BUTYL ALCOHOL |
3 |
||
sec-BUTYL ALCOHOL |
3 |
||
tert-BUTYL ALCOHOL |
3 |
||
2-CHLOROETHANOL |
6.1/3 |
||
ETHANOL |
The vapour mixes well with air, explosive mixtures are easily formed |
On combustion, forms toxic gases • Reacts slowly with calcium hypochlorite, silver oxide and ammonia, causing fire and explosion hazard • Reacts violently with strong oxidants such as nitric acid, silver nitrate, mercuric nitrate or magnesium perchlorate, causing fire and explosion hazard |
3 |
2-ETHYL-1-HEXANOL |
Reacts vigorously with oxidizing materials |
||
HEXANOL |
3 |
||
ISOAMYL ALCOHOL |
Vapour mixes readily with air |
Reacts with strong oxidants |
|
ISOBUTYL ALCOHOL |
3 |
||
ISODECYL ALCOHOL |
The substance decomposes on heating producing acrid smoke and fumes • Reacts with strong oxidants |
||
ISOOCTYL ALCOHOL |
The substance decomposes on heating producing acrid smoke and fumes • Reacts with strong oxidants (analogy with isodecyl alcohol) |
||
ISOPROPYL ALCOHOL |
The vapour mixes well with air, explosive mixtures are easily formed |
Reacts with strong oxidants |
3 |
METHANOL |
The vapour mixes well with air, explosive mixtures are easily formed |
Reacts violently with oxidants causing fire and explosion hazard |
3/ 6.1 |
3-METHOXY-1-BUTANOL |
Reacts with oxidants |
||
2-METHYL-4-PENTANOL |
The vapour is heavier than air and may travel along the ground; distant ignition possible |
Reacts with oxidants • Reacts violently with alkali metals causing fire and explosion hazard |
3 |
METHYLCYCLOHEXANOL |
On combustion, forms toxic gases |
3 |
|
o-METHYLCYCLOHEXANOL |
3 |
||
m-METHYLCYCLOHEXANOL |
3 |
||
1-PENTANOL |
The vapour mixes well with air, explosive mixtures are easily formed |
Reacts violently with oxidants |
3 |
3-PENTANOL |
The vapour is heavier than air and may travel along the ground; distant ignition possible |
Reacts with strong oxidants |
3 |
2-PHENYLETHANOL |
Reacts with strong oxidants, strong acids |
||
PROPANOL |
The vapour mixes well with air, explosive mixtures are easily formed |
Reacts with strong oxidants (perchlorates, nitrates) |
3 |
PROPARGYL ALCOHOL |
The vapour is heavier than air |
Reacts violently with oxidants • Attacks many plastics • On contact with heavy metals, poorly soluble salts may be formed, which may explode on heating |
|
TETRAHYDROFURFURYL ALCOHOL |
The substance can presumably form explosive peroxides • The substance decomposes on heating producing acrid smoke and fume • Reacts violently with strong oxidants, several n-chloro- and n-bromoimides causing fire and explosion hazard • Attacks many resins and organic materials |
||
3,5,5-TRIMETHYL 1-HEXANOL |
The vapour is heavier than air |
May explode on heating • Reacts with strong oxidants, inorganic acids, aldehydes, alkenoxides, acid anhydrides • Reacts with rubber, PVC |
For UN Class: 1.5 = very insensitive substances which have a mass explosion hazard; 2.1 = flammable gas; 2.3 = toxic gas; 3 = flammable liquid; 4.1 = flammable solid; 4.2 = substance liable to spontaneous combustion; 4.3 = substance which in contact with water emits flammable gases; 5.1 = oxidizing substance; 6.1 = toxic; 7 = radioactive; 8 = corrosive substance.
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